Hepatic metabolic derangements are key components in the development of fatty liver, insulin
resistance, and atherosclerosis. SIRT1, a NAD + -dependent protein deacetylase, is an …

Immune checkpoint blockade targeting PD-1/PD-L1 has promising therapeutic efficacy in a
variety of tumors, but resistance during treatment is a major issue. In this review, we describe …

Single-cell RNA sequencing (scRNA-seq), a technology that analyzes transcriptomes of
complex tissues at single-cell levels, can identify differential gene expression and epigenetic …

The NAD + -dependent deacetylase Sir2 regulates life span in lower eukaryotes. The mammalian
ortholog SIRT1 regulates physiological processes including apoptosis, fat metabolism, …

Tumor immune escape is an important strategy of tumor survival. There are many mechanisms
of tumor immune escape, including immunosuppression, which has become a research …

Circular RNAs (circRNAs) are connected at the 3′ and 5′ ends by exon or intron cyclization,
forming a complete ring structure. circRNA is more stable and conservative than linear …

Tumor angiogenesis is necessary for the continued survival and development of tumor cells,
and plays an important role in their growth, invasion, and metastasis. The tumor …

Genetic instability of tumor cells often leads to the occurrence of a large number of mutations,
and expression of non-synonymous mutations can produce tumor-specific antigens called …

c-Met is a receptor tyrosine kinase belonging to the MET (MNNG HOS transforming gene)
family, and is expressed on the surfaces of various cells. Hepatocyte growth factor (HGF) is the …

Non-coding RNAs do not encode proteins and regulate various oncological processes. They
are also important potential cancer diagnostic and prognostic biomarkers. Bioinformatics …