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Characteristics Upper limbs study (N=127) Lower limbs study (N=137) Mean±SD 31.9±10.4 33.7±11.1 Age (years) Range 20 − 65 20 − 66 20 − 29 64 60 30 − 39 31 36 40 − 49 25 28 50 − 59 5 10 >60 2 3 Gender n (%) Male 40 (31.5) 46 (33.6) Female 87 (68.5) 91 (66.4) Height (cm) Mean±SD 163.4±9.1 163.0±9.4 Range 131 − 189 131 − 189 Weight, (kg) Mean±SD 72.0±15.8 74.3±17.9 Range 37 − 130 37 − 130 BMI Mean±SD 26.9±5.4 27.9±6.2 Range 15.0 − 50.8 15.0 − 50.8 BMI, body mass index Nerve n Amplitude (mV) DML (ms) Conduction velocity (m/s) % Amplitude drop in forearm or leg % Amplitude drop across elbow or FH Mean±SD (range) Median motor 119 11.5±2.4 (7.0 – 18.8) 3.0±0.36 (2.2 – 3.8) 57.8±4.1 (50 – 72) 6.1±6.1 (0.0 – 31.4) ___ Ulnar motor 119 10.0±1.6 (7.0 – 15.9) 2.6±0.33 (1.4 – 3.5) 60.6±4.6 (49 – 71)* 7.0±4.8 (0.0 – 23.8)† 3.1±3.5 (0.0 – 16.3)† Tibial motor 134 13.3±3.5 (4.6 – 22.8) 3.8±0.7 (2.2 – 5.9) 50.1±5.7 (35 – 64) 28.7±13.5 (0.0 – 74.8) ___ Fibular motor 134 5.2±1.9 (1.1 – 12.3) 3.9±0.6 (2.0 – 5.5) 49.5±4.9 (36 – 69)‡ 11.1±7.9 (0.0 – 43.9) 1.4±5.3 (0.0 – 22.5) ↵* Ulnar motor conduction velocity across the elbow was 69.5±8.0 (52 – 91) m/s, † Two participants with Martin-Gruber anastomosis were excluded, ‡ Fibular motor conduction velocity across fibular head was 58.7±9.1 (38 – 90) m/s, No absent responses. DML - distal motor latency, D2 - index finger, D4 - ring finger, D5 - little finger, FH - fibular head
Nerve Age Amplitude (mV) DML (ms) Conduction velocity (m/s) Conduction velocity across elbow or FH (m/s) % amplitude drop in the forearm or leg segment % amplitude drop across elbow or FH 2nd percentile (LLN) † 97th percentile (ULN) ‡ 3rd percentile (LLN) † 3rd percentile (LLN) † 97th percentile (ULN) ‡ 97th percentile (ULN) ‡ Median motor N=119β0* = 2.129 (2.006), β1* = –0.004 (–0.008) 20 7.8 (6.3) 3.7 (3.8) 50 (50) ___ 21.8 (31.4) ___ 40 7.2 (5.4) 60 6.6 (4.6) Ulnar motor N=119β0* = 2.212 (2.048), β1=–0.004 (–0.008) 20 8.4 (6.6) § 3.3 (3.5) 50 (49) 52 (52); slowing compared with the forearm segment = 8 m/s (maximum = 9 m/s) 20.4 (23.8) 11.3 (16.3) 40 7.8 (5.6) § 60 7.2 (4.8) § Tibial motor N=134 20 – 66 7.1 (4.6) 5.8 (5.9) 40 (35) ___ 58.0 (74.8) ∫ ___ Fibular motor N=134β0* = 2.048 (1.841), β1= –0.038 (–0.046) 20 3.6 (2.5) 5.0 (5.5) 40 (36) 43 (38); slowing compared with the leg segment = 5 m/s (maximum = 16 m/s) 30.0 (44.0) 14.5 (22.5) 40 1.7 (1.0) 60 0.8 (0.4) ↵* Regression coefficients obtained from the quantile regression model: log (predicted value)= β0 + β1 ×(age), † LLN represents the lower limit of the 95% confidence interval at minimum values in the sample, ‡ ULN represents the upper limit of the 95% confidence interval at maximum values in the sample, § Regression model for ulnar CMAP amplitude was estimated at the 5th percentile, as it was not significant at the lower percentiles, ∫ Drop in tibial amplitude with stimulation at popliteal fossa should be interpreted cautiously because supramaximal stimulation may not have been achieved due to pain and technical factors, Data are combined for NCS parameters with no age effect. Age was not significantly associated with tibial CMAP amplitude. Therefore, the reference limit was calculated for the entire group, DML - distal motor latency, FH - fibular head, CMAP - compound muscle action potential, NCS - nerve conduction study
F-wave Height (cm) Minimal latency (ms), 95th percentile Minimal latency, Mean ± SD (range) Median n=108 150 24 24.5±2.1 (20.9 - 30.4) 165 27 180 31 β0*
β1*-8.374
0.217Ulnar n=95 150 25 24.7±2.2 (20.1 - 30.3) 165 28 180 31 β0*
β1*-5.500
0.200Tibial n=98 150 46 45.4±4.0 (35.4 - 56.3) 165 51 180 57 β0*
β1*-9.930
0.370Fibular n=98 150 43 43.9±3.7 (35.7 - 53.6) 165 48 180 54 β0*
β1-11.650
0.364↵* Regression coefficients obtained from the quantile regression model: Predicted F-wave minimal latency = β0 + β1 ×(height in cm)