Clinical and epidemiological profile of cerebral venous thrombosis ================================================================== * Mohammed S. Alqahtani * Adel A. Alhazzani * Ibrahim Alnaami * Saeed A. Alqahtani * Tariq M. Alahmari * Abdulaziz M. Alqarni * Ibrahim A. Alburaidi * Mohammed A. Alqahtani * Saleh M. Alqahtani * Moayad A. Zarbh * Yasser wassel * Jaber Alfaifi * Ahmed Elhadad ## Abstract **Objectives:** To assess the epidemiological pattern and correlates with the clinical outcome of Cerebral venous thrombosis (CVT) in Abha, Kingdom of Saudi Arabia. **Methods:** A retrospective record-based cohort design was conducted including all patients admitted with diagnosis of CVT in 2 main tertiary hospitals in Aseer Region between 2015 to the end of 2018. The study hospitals were Aseer Central Hospital and Armed Forces Hospitals Southern Region. The data were collected by structured data sheets, including sociodemographic data. Assessment of known risk factors for CVT, clinical presentation, treatment received, and clinical outcome after treatment were extracted. **Results:** The study included 119 patients with CVT, whose ages ranged from 15 to 97 years, with a mean age of 35.5-+14.1 years. Majority of the patients were females (81.5%). Headache was the most presenting (82.4%) symptom, followed by vomiting (30.3%) and a decreased level of consciousness. Thirty-three cases (27.7%) had complications, and recanalization was recorded among 92 cases (94.8%) based on follow up vascular imaging. **Conclusion:** The study revealed that most of the cases of CVT had favorable clinical outcome and recanalization, especially those who had a shorter duration untildiagnosis. Young females were the most affected group. Cerebral venous thrombosis (CVT) accounts for 0.5% to 1% of all strokes. Younger women are at high risk among other groups.1 The most presenting symptoms are headaches, focal neurological deficit, a decreased level of consciousness (LOC), seizures, or even intracranial hypertension with no focal neurological signs.2,3 Daif et al. reported a frequency in Saudi Arabia of 7 cases per 100,000 hospital patients.4 A prospective population-based survey conducted in the Isfahan region of Iran, between 2001 and 2004, reported an annual incidence of CVT of 12.1 per million people.5 A study of the anatomy of the venous system is essential to help evaluate patients with CVT, The venous circulation of the brain is drained to the superficial and the deep venous system. The drained blood runs into the major dural sinuses: the superior sagittal sinus (SSS), the inferior sagittal sinus (ISS), the lateral sinus (LS), the cavernous sinus, the straight sinus, and finally the internal jugular vein (IJV). Difficulties in diagnosis in some cases is due to high proportion of anastomoses between these 2 cerebral venous systems.6,7 Multiple predisposing factors of CVT exist. Many cases have been linked to inherited and acquired thrombophilia, pregnancy, puerperium, infection, and malignancy. Infarctions due to CVT are often hemorrhagic and associated with vasogenic edema.8 MRI with T1, T2, fluid-attenuated inversion recovery, and T2* sequences, in addition to magnetic resonance angiography, are the best diagnostic tools. D-dimer concentrations are elevated in the majority of patients, but normal D-dimers do not exclude CVT, especially in patients who present with only headaches.9 Treatment should start as soon as the diagnosis is confirmed. Treatment methods include reversing the underlying cause, control of seizures and intracranial hypertension, and antithrombotic therapy. Anticoagulation is the pillar of acute and sub-acute treatment for CVT.8,9 This research aims to identify the patterns and different risk factors associated with CVT, in addition to assessing the clinical outcome for CVT cases with treatment modalities. To the best of our knowledge, no similar study has been done in aseer region uptodate. ## Methods A retrospective record-based cohort design was conducted targeting all the accessible medical files of patients who had CVT in 2 main tertiary hospitals in Aseer Region between 2015 to the end of 2018 with Confirmed Diagnosis of CVT by either CT Venogram or MR Venogram in adults 14 years and older, the study excluded pediatric population and clinical suspected CVT without vascular imaging. The study hospitals were Aseer Central Hospital and Armed Forces Hospitals Southern Region, Southern Saudi Arabia. They are the main tertiary hospitals in Aseer Region, to which nearly all cases are referred to receive treatment. The data were collected by structured data sheets, including socio demographic data (age, gender, work, marital status, and nationality). Assessment of known risk factors for CVT, clinical presentation, treatment received, and clinical outcome after treatment were extracted. The data were extracted from the hospital records after obtaining ethical approval. ### Data analysis Data was collected, reviewed and validated, then analyzed using IBM SPSS version 22 (SPSS, Inc. Chicago, IL) statistical software. All statistical analyses were carried out using a two-tailed test. A *p*-value less than 0.05 was considered to be statistically significant. Descriptive analysis based on frequency and percentage distributions was carried out for all variables, including demographic data, risk factors, and patterns and outcomes of CVT. Univariant relations between patients’ biodemographic and clinical data with CVT clinical outcomes were determined based on exact probability tests because of small frequencies. ## Results The study included 119 patients with CVT whose ages ranged from 15 to 97 years, with a mean age of 35±14 years. Majority of cases 97 (81.5%) were females, of whom 71.4% were married. Education of a secondary degree or higher was recorded for 62.2% of the cases, 52.9% of the cases were not working, and 10.9% of the cases were students. Exactly 65.5% of the participants resided in high-altitude areas (Table 1). View this table: [Table 1](http://nsj.org.sa/content/25/5/380/T1) Table 1 Personal data of patients with Cerebral Venous Thrombosis, Aseer Region-Southern of Saudi Arabia. As for the clinical presentation of CVT recorded among the study cases (Figure 1), headache was the most frequent (82.4%) symptom, followed by vomiting (30.3%), decreased LOC (28.6%), weakness (22.7%), and nausea (10.1%). ![Figure 1](http://nsj.org.sa/https://nsj.org.sa/content/nsj/25/5/380/F1.medium.gif) [Figure 1](http://nsj.org.sa/content/25/5/380/F1) Figure 1 Clinical presentation of patients with Cerebral Venous Thrombosis, Aseer Region-Southern of Saudi Arabia. Table 2 demonstrates the pattern of CVT among the study cases. Forty-two percent of the patients presented within 2 days from symptoms onset. The CTV was carried out for 52.9% of the cases, and CT with MRI was needed for 58% of the cases. About 39% of the cases had 3-5 hours until undergoing CT, and intra cerebral hemorrhage was recorded for 41.9% of the cases. Also, 28.4% of the cases underwent MRI after 24 hours, while the majority of the cases (84.9%) were diagnosed within two days from hospitalization. Imaging recorded that superior sagittal sinus were the most commonly involved in isolation (21.8%) followed by transverse sinus, both sinuses were affected in 13.4 % of the cases. The CVT was on the left side for 58% of the cases. View this table: [Table 2](http://nsj.org.sa/content/25/5/380/T2) Table 2 Pattern of CVT among affected patients, Aseer Region-Southern of Saudi Arabia. Family history was significant for thromboembolic diseases in more than on forth 28.6% of the cases, and 11.8% of them were diabetic. Recurrent CVT was seen for 5% of the cases, while history of DVT founded in 8.4%. About one third 31% of the female cases took OCP, and 44.3% were found to have hypercoaguable state (Table 3). View this table: [Table 3](http://nsj.org.sa/content/25/5/380/T3) Table 3 Risk factors of CVT among affected patients, Aseer Region-Southern of Saudi Arabia. As for the clinical assessment of cases on admission, Table 4 illustrates that 95.8 % of the cases achieved the good and favorable clinical outcome (0-2) based on Modified Rankin Scale (mRs), 2 cases were critical and one of them died after he went for surgical intervention. Only 23 patients (19.3%) were stayed for more than 2 weeks in the hospital, and 71.4% had IV heparin on admission. Fifteen cases (12.6%) were discharged on NOAC. View this table: [Table 4](http://nsj.org.sa/content/25/5/380/T4) Table 4 Admission data of patients with Cerebral Venous Thrombosis, Aseer Region-Southern of Saudi Arabia. Regarding the clinical outcome, 33 cases (27.7%) had complications, and recanalization was recorded for 92 cases (94.8%) based on follow-up imaging. Finally, relating the clinical outcome with the case factors (Table 5) revealed that all cases who had symptoms for 1-2 days only were completely recovered, compared with 92.3% of those who had symptoms for 7 days or more (with a statistical significance of *p*-value=.048). Also, 86.2% of the patients who had complications recovered, compared with 98.5% of those who did not (*p*=.012). All other factors were not statistically significantly related to the clinical outcome. View this table: [Table 5](http://nsj.org.sa/content/25/5/380/T5) Table 5 Predictors of recanalization among patientswith Cerebral Venous Thrombosis, Aseer Region-Southern of Saudi Arabia. ## Discussion Cerebral venous sinus thrombosis (CVST) occurs as result of limitation of venous flow due to presence of a blood clot in the dural venous sinuses, which drain blood from the brain. Symptoms may include headache, abnormal vision, any of the symptoms of stroke such as weakness of the face and limbs on one side of the body, and seizures.10⇓–12 The diagnosis is usually made by computed tomography (CT scan) or magnetic resonance imaging (MRI) to demonstrate obstruction of the venous sinuses.10,12,13 Treatment is typically with anticoagulants (medication that suppresses blood clotting) such as low molecular weight heparin.14 Thrombolytic (enzymatic destruction of the blood clot) is rarely used. The disease may be complicated by raised intracranial pressure, which may warrant surgical intervention such as the placement of a shunt.15 rarely endovascular interventions may be used in selected cases that does not respond to medical therapy.16 The current study aimed to assess the epidemiological pattern of CVT among cases, including site, affected sinuses, laterality, and risk factors. Also, we aimed to detect the clinical outcome for the cases in relation to different factors, including treatment received. The study revealed that most of the CVT cases were young females below the age of 40 years, with the most recorded risk factors are history of miscarriage and taking oral contraceptive pills (OCP). Furthermore, high altitude was also recorded more among CVT cases, maybe due to the nature of the Abha area or the association of high altitude with high blood viscosity. Headache, vomiting, and deteriorated consciousness were the most recorded symptoms, which are all nonspecific and may be confused with any less serious clinical cases, resulting in delayed seeking for medical advice; this was actually the situation as more than half of the cases needed 3 days or more before consulting medical advice. As for imaging, more than half of the cases required both CT and MRI to be diagnosed, and hemorrhage was the most recorded finding, while in one third of the cases the imaging was normal. The superior sagittal sinus were the most commonly involved in isolation followed by transverse sinus, especially on the left side. As for risk factors, family history was dominant, followed by DM in general, but a history of having hypercoagulopathy state and OCP were the most dominant factors for females. Recanalization was recorded for majority of the cases as only 5 cases showed failed recanalization on follow-up imaging. Outcomes of patients who were discharge on NOAC were comparable to those on warfarin but the number was small (15 cases 12.6%) to draw solid conclusion. A for comparison with the study was conducted by Algahtani et al17 in Saudi Arabia to analyze the clinical patterns, etiologies, treatment, and outcome of CVST in 2 major cities of Saudi Arabia: Jeddah and Al-Baha.The researchers reported 92 adults and 19 children with CVST. Among the adults, females were the most affected, while also more males than females were affected. The mean age of onset was 29.5 years. The most recorded clinical presentations were headache, focal neurologic deficits, seizures, papilledema, and a decreased level of consciousness. The main risk factors recorded were pregnancy/puerperium, antiphospholipid antibody syndrome, oral contraceptive pills, malignancy, and infections. The superior sagittal sinus (24.3%) was the most common site of CVST. Seventy-four patients recovered completely, 23 patients recovered partially, and 10 patients died. Bad prognostic factors included incurable co-morbid conditions, late presentation, and status epilepticus. All are consistent with the current study findings. Results of our study are in line with previously published data from western part of Saudi Arabia in terms of clinical presentations and risk factors, however outcome in our study population was slightly better. This could be due to increased awareness and earlier diagnosis and treatment, as nearly half of the patient establish diagnosis within 48 hrs. The limitations of this study as a retrospective study include selection bias and potential for non-measurable confounders; therefore, multicenter prospective studies are needed in the future. Overall, CVT is not a rare disease and may lead to death or disability if not diagnosed and treated promptly. Diagnosis can be challenging due to variable and nonspecific symptoms therefore high index of suspension is required and utilization of readily available diagnostic imaging is mandatory to confirm the diagnosis. A better understanding of the epidemiological pattern, including the most frequent presentations and associated risk factors, may help in reducing this management gap. In conclusions, the study revealed that most of the cases of CVT had favorable clinical and radiological outcomes, in particular when diagnosed within 48 hours. Young females living at high altitude were the most affected group. Using OCP and presence of hypercoagulopathy state were the most prominent risk factors among females. More than half of the cases needed more than 48 hours for presentation and diagnosis which indicates the need to raise awareness of target population about this condition. ## Acknowledgements We would like to thank ProofreadingServices.com, for English language editing. We acknowledge that first and second Authors contributed equally to this manuscript. ## Footnotes * **Disclosure.** Authors have no conflict of interests, and the work was not supported or funded by any drug company. * Received February 28, 2020. * Accepted July 2, 2020. * Copyright: © Neurosciences Neurosciences is an Open Access journal and articles published are distributed under the terms of the Creative Commons Attribution-NonCommercial License (CC BY-NC). Readers may copy, distribute, and display the work for non-commercial purposes with the proper citation of the original work. ## References 1. Danwang C, Mazou TN, Tochie JN, Tankeu R, Bigna JJ (2018) Global epidemiology and patterns of cerebral venous thrombosis: a systematic review and meta-analysis protocol. BMJ Open 8, e019939. 2. Tadi P, Behgam B, Baruffi S (2020) Cerebral Venous Thrombosis (Statpearls Publishing, Treasure Island (FL)). 3. 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