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Research ArticleOriginal Article
Open Access

Poloxamer 188 alleviates cerebral ischemia-reperfusion injury in mice by reducing mitochondrial and lysosomal membrane damage

Hui Xu, Zhanhu Zhang, Xiaodong Tao, Ruirui Shi, Jian Xu, Xiaohua Zhang and Jinhua Gu
Neurosciences Journal July 2025, 30 (3) 216-225; DOI: https://doi.org/10.17712/nsj.2025.3.20240025
Hui Xu
From Nantong Institute of Genetics and Reproductive Medicine (Xu, Zhang, Shi, Xu, Gu), Affiliated Maternity & Child Healthcare Hospital of Nantong University, from Nantong Key Laboratory of Genetics and Reproductive Medicine (Xu, Zhang, Shi, Xu, Gu), from the Department of High-Quality Development (Tao), Affiliated Maternity & Child Healthcare Hospital of Nantong University, and Department of Pediatrics (Zhang), Affiliated Maternity & Child Healthcare Hospital of Nantong University, Nantong, China.
MD, PhD
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Zhanhu Zhang
From Nantong Institute of Genetics and Reproductive Medicine (Xu, Zhang, Shi, Xu, Gu), Affiliated Maternity & Child Healthcare Hospital of Nantong University, from Nantong Key Laboratory of Genetics and Reproductive Medicine (Xu, Zhang, Shi, Xu, Gu), from the Department of High-Quality Development (Tao), Affiliated Maternity & Child Healthcare Hospital of Nantong University, and Department of Pediatrics (Zhang), Affiliated Maternity & Child Healthcare Hospital of Nantong University, Nantong, China.
PhD
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Xiaodong Tao
From Nantong Institute of Genetics and Reproductive Medicine (Xu, Zhang, Shi, Xu, Gu), Affiliated Maternity & Child Healthcare Hospital of Nantong University, from Nantong Key Laboratory of Genetics and Reproductive Medicine (Xu, Zhang, Shi, Xu, Gu), from the Department of High-Quality Development (Tao), Affiliated Maternity & Child Healthcare Hospital of Nantong University, and Department of Pediatrics (Zhang), Affiliated Maternity & Child Healthcare Hospital of Nantong University, Nantong, China.
MS
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Ruirui Shi
From Nantong Institute of Genetics and Reproductive Medicine (Xu, Zhang, Shi, Xu, Gu), Affiliated Maternity & Child Healthcare Hospital of Nantong University, from Nantong Key Laboratory of Genetics and Reproductive Medicine (Xu, Zhang, Shi, Xu, Gu), from the Department of High-Quality Development (Tao), Affiliated Maternity & Child Healthcare Hospital of Nantong University, and Department of Pediatrics (Zhang), Affiliated Maternity & Child Healthcare Hospital of Nantong University, Nantong, China.
MS
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Jian Xu
From Nantong Institute of Genetics and Reproductive Medicine (Xu, Zhang, Shi, Xu, Gu), Affiliated Maternity & Child Healthcare Hospital of Nantong University, from Nantong Key Laboratory of Genetics and Reproductive Medicine (Xu, Zhang, Shi, Xu, Gu), from the Department of High-Quality Development (Tao), Affiliated Maternity & Child Healthcare Hospital of Nantong University, and Department of Pediatrics (Zhang), Affiliated Maternity & Child Healthcare Hospital of Nantong University, Nantong, China.
MS
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Xiaohua Zhang
From Nantong Institute of Genetics and Reproductive Medicine (Xu, Zhang, Shi, Xu, Gu), Affiliated Maternity & Child Healthcare Hospital of Nantong University, from Nantong Key Laboratory of Genetics and Reproductive Medicine (Xu, Zhang, Shi, Xu, Gu), from the Department of High-Quality Development (Tao), Affiliated Maternity & Child Healthcare Hospital of Nantong University, and Department of Pediatrics (Zhang), Affiliated Maternity & Child Healthcare Hospital of Nantong University, Nantong, China.
MS
Roles: Pro.f
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Jinhua Gu
From Nantong Institute of Genetics and Reproductive Medicine (Xu, Zhang, Shi, Xu, Gu), Affiliated Maternity & Child Healthcare Hospital of Nantong University, from Nantong Key Laboratory of Genetics and Reproductive Medicine (Xu, Zhang, Shi, Xu, Gu), from the Department of High-Quality Development (Tao), Affiliated Maternity & Child Healthcare Hospital of Nantong University, and Department of Pediatrics (Zhang), Affiliated Maternity & Child Healthcare Hospital of Nantong University, Nantong, China.
MD, PhD
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  • ORCID record for Jinhua Gu
  • For correspondence: jhgu{at}ntu.edu.cn
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Poloxamer 188 alleviates cerebral ischemia-reperfusion injury in mice by reducing mitochondrial and lysosomal membrane damage
Hui Xu, Zhanhu Zhang, Xiaodong Tao, Ruirui Shi, Jian Xu, Xiaohua Zhang, Jinhua Gu
Neurosciences Journal Jul 2025, 30 (3) 216-225; DOI: 10.17712/nsj.2025.3.20240025

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Poloxamer 188 alleviates cerebral ischemia-reperfusion injury in mice by reducing mitochondrial and lysosomal membrane damage
Hui Xu, Zhanhu Zhang, Xiaodong Tao, Ruirui Shi, Jian Xu, Xiaohua Zhang, Jinhua Gu
Neurosciences Journal Jul 2025, 30 (3) 216-225; DOI: 10.17712/nsj.2025.3.20240025
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