PT  - JOURNAL ARTICLE
AU  - Gurbilek, Mehmet
AU  - Topcu, Cemile
AU  - AkOz, Mehmet
AU  - Bariskaner, Hulagu
AU  - Ustun, Mehmet E.
AU  - KOylu, Oznur
TI  - Effect of deferoxamine on Na+K+ATPase activity after cerebral ischemia in rabbits
DP  - 2006 Apr 01
TA  - Neurosciences Journal
PG  - 88--92
VI  - 11
IP  - 2
4099  - http://nsj.org.sa/content/11/2/88.short
4100  - http://nsj.org.sa/content/11/2/88.full
SO  - Neurosciences (Riyadh)2006 Apr 01; 11
AB  - OBJECTIVE: To study the effects of deferoxamine on tissue sodium-potassium adenosine triphosphatase (Na+-K+ ATPase) activity on cerebral ischemia in rabbits.METHODS: We cared for the animals in the Pharmacology Department of the Medical School of Selcuk University in 2004. We used 30, New Zealand, 7-day-old male rabbits in the experiment. We anesthetized all the animals with xylazine hydrochloric acid and ketamine. We divided the rabbits equally into 3 groups. In group 1 (n=10) (sham group), we observed baseline levels, and did not apply ischemia. In group 2 (n=10) (untreated group) we produced cerebral ischemia by clamping the bilateral common carotid arteries for 60 minutes, and in group 3 (n=10), we administered deferoxamine (DFO) 50 mg/kg intravenously immediately after opening the clamps. RESULTS: The Na+-K+ATPase activity increased after DFO treatment (p=0.045).CONCLUSION: We conclude that Na+-K+ATPase activity in cortical brain tissue was higher in DFO-treated rabbits compared with untreated animals after ischemia.