PT  - JOURNAL ARTICLE
AU  - Saadah, Mohammed A.
AU  - Thakre, Mona C.
AU  - Saadah, Loai M.
AU  - Nazzal, Mahmoud E.
TI  - Homocystinemia and stroke in vegetarians
DP  - 2006 Apr 01
TA  - Neurosciences Journal
PG  - 107--111
VI  - 11
IP  - 2
4099  - http://nsj.org.sa/content/11/2/107.short
4100  - http://nsj.org.sa/content/11/2/107.full
SO  - Neurosciences (Riyadh)2006 Apr 01; 11
AB  - Homocysteine is a sulfurated amino acid with a central role in the metabolism of thiol compounds. Homocystinemia is a recognized independent potentially remediable risk factor for vascular disease. It is associated with both macro and micro vascular ischemic stroke. It can often be normalized by polyvitamin therapy. This inexpensive and well-tolerated treatment is considered effective in decreasing the incidence of stroke. We report 2 young strict vegetarians with no known vascular risk factors. The first suffered a left middle cerebral artery infarct, and the second multiple bilateral small cerebral infarctions. Extensive investigations showed moderately elevated homocysteine and low serum B12 levels, suggesting that these are most probably the underlying etiology. We believe that a high index of suspicion is needed, particularly in younger people with a potential underlying cause for B12 deficiency and no identifiable stroke risk factor.