PT  - JOURNAL ARTICLE
AU  - Kunduracioglu, Burak
AU  - Ulkar, Bulent
AU  - Sabuncuoglu, Bizden T.
AU  - Can, Belgin
AU  - Bayrakci, Kenan
TI  - Effects of hypertonic dextrose on injured rat skeletal muscles
DP  - 2006 Apr 01
TA  - Neurosciences Journal
PG  - 93--96
VI  - 11
IP  - 2
4099  - http://nsj.org.sa/content/11/2/93.short
4100  - http://nsj.org.sa/content/11/2/93.full
SO  - Neurosciences (Riyadh)2006 Apr 01; 11
AB  - OBJECTIVE: Histological examination of proliferative therapy effects on the healing process of muscular injury.METHODS: We performed this study between March and August 2002 at Ankara University, School of Medicine, Laboratory of Animal Experiments, Ankara, Turkey. We used an experimental animal model by conducting a standardized cut injury of the gastrocnemius muscle in 30 adult male albino rats, which we divided into 2 groups; proliferative therapy group and control group. We evaluated the injured rat muscles by light microscopy on the fifth, eight, and twelfth day of injury.RESULTS: The muscular regeneration process began at day 5 in both the control and proliferative therapy groups. The proliferative therapy group revealed a prominent inflammatory reaction, fibroblast migration, and necrosis with accompanying regeneration and excessive connective tissue formation.CONCLUSION: We cannot consider proliferative therapy an appropriate treatment modality for muscular injuries, unless there is evidence of normal muscle physiology and biomechanics post traumatically.