RT Journal Article
SR Electronic
T1 Effects of hypertonic dextrose on injured rat skeletal muscles
JF Neurosciences Journal
JO Neurosciences (Riyadh)
FD Prince Sultan Military Medical City
SP 93
OP 96
VO 11
IS 2
A1 Kunduracioglu, Burak
A1 Ulkar, Bulent
A1 Sabuncuoglu, Bizden T.
A1 Can, Belgin
A1 Bayrakci, Kenan
YR 2006
UL http://nsj.org.sa/content/11/2/93.abstract
AB OBJECTIVE: Histological examination of proliferative therapy effects on the healing process of muscular injury.METHODS: We performed this study between March and August 2002 at Ankara University, School of Medicine, Laboratory of Animal Experiments, Ankara, Turkey. We used an experimental animal model by conducting a standardized cut injury of the gastrocnemius muscle in 30 adult male albino rats, which we divided into 2 groups; proliferative therapy group and control group. We evaluated the injured rat muscles by light microscopy on the fifth, eight, and twelfth day of injury.RESULTS: The muscular regeneration process began at day 5 in both the control and proliferative therapy groups. The proliferative therapy group revealed a prominent inflammatory reaction, fibroblast migration, and necrosis with accompanying regeneration and excessive connective tissue formation.CONCLUSION: We cannot consider proliferative therapy an appropriate treatment modality for muscular injuries, unless there is evidence of normal muscle physiology and biomechanics post traumatically.