RT Journal Article
SR Electronic
T1 Histopathologic evaluation of neurogenic pulmonary edema after subarachnoid hemorrhage in rabbits
JF Neurosciences Journal
JO Neurosciences (Riyadh)
FD Prince Sultan Military Medical City
SP 158
OP 161
VO 11
IS 3
A1 Gundogdu, Cemal
A1 Kizilkaya, Mehmet
A1 Aydin, Mehmet D.
A1 Atalay, Canan
A1 Sevimli, Zuhtu U.
YR 2006
UL http://nsj.org.sa/content/11/3/158.abstract
AB OBJECTIVE: To investigate the effects of subarachnoid hemorrhage (SAH) on lung tissue.METHODS: We conducted this study on 20 rabbits in the Ataturk University Medical Faculty, Erzurum, Turkey in 2005. Experimental SAH was applied to all animals under general anesthesia. After 20 days, all animals were sacrificed. Their lungs were examined histopathologically. RESULTS: Foamy hemorrhagic parenchymal lesions, alveolar rupture, and subintimal fluid collection in the pulmonary vasculature were observed in the lungs of the non-surviving animals. However, minimal changes were found in the lungs of the surviving animals (p<0.01).CONCLUSION: Our results suggest that luminal narrowing of the lung vessels due to subintimal fluid collection plays an important role in the development of pulmonary hypertension and neurogenic pulmonary edema in SAH.