RT Journal Article
SR Electronic
T1 Clinicopathological features of primary central nervous system lymphoma
JF Neurosciences Journal
JO Neurosciences (Riyadh)
FD Prince Sultan Military Medical City
SP 284
OP 288
VO 11
IS 4
A1 Moradi, Afshin
A1 Tajedini, Aram
A1 Mehrabian, Abbasali
A1 Sadeghi, Sohrab
A1 Semnani, Vahid
A1 Khodabakhshi, Reza
A1 Arefian, Noormohammad
A1 Afrakhteh, Maryam
A1 Keshvari, Kayvan
A1 Yavari, Parvin
A1 Madani-Civi, Manouchehr
YR 2006
UL http://nsj.org.sa/content/11/4/284.abstract
AB OBJECTIVE: To investigate the anatomic location, immunologic, and clinicopathological features of patients with primary central nervous system lymphoma (PCNSL).METHODS: From May 1993 to December 2004, at Shohada Hospital, Tehran, Iran, the clinical data of 110 PCNSL patients, including the age, sex, duration of symptoms, radiological findings, site of tumors, immune status, and history of immunocompromised state (such as organ transplantation, radiotherapy, steroid therapy or AIDS) were assessed.RESULTS: The mean age of the patients with PCNSL was 47.02 +/- 15.8 years. There were 42 female and 68 male patients. One hundred and six cases (96.3%) were diagnosed as B-cell lymphoma. Most of the PCNSL in our study are unifocal. More than 70% of tumors were in a cerebral hemisphere and periventricular location, usually involving the corpus callosum or basal ganglia. No patients had been in immunocompromised states. Symptoms of increased intracranial pressure or changes in personality, vision, or motor function are most common. Seizures are seen in approximately 10% of patients. The number of PCNSL cases showed a gradual rise in incidence.CONCLUSION: The results of this single hospital 12-year survey of PCNSL are in agreement with data from other single institutions and regional surveys concerning clinical features. However, in contrast with the literature, most of our patients were immunocompetent. The age at diagnosis is also lower than in most reports.