PT - JOURNAL ARTICLE AU - Koul, Roshan AU - Al-Futaisi, Amna AU - Williams, Ranjan AU - Javad, Hashim AU - Chacko, Alexander TI - Transient opsoclonus-myoclonus syndrome secondary to neuroblastoma DP - 2007 Jul 01 TA - Neurosciences Journal PG - 253--255 VI - 12 IP - 3 4099 - http://nsj.org.sa/content/12/3/253.short 4100 - http://nsj.org.sa/content/12/3/253.full SO - Neurosciences (Riyadh)2007 Jul 01; 12 AB - We report a 2.5-year-old girl who presented with acute history of fluctuating level of consciousness in the form of drowsiness, extreme irritability, and involuntary abnormal movements in the form of shaking of the whole body. She was treated with acyclovir empirically, contemplating herpes simplex virus encephalitis. Overtime she improved substantially. The opsoclonus, myoclonus, and ataxia disappeared without treatment. However, 6 weeks later she presented again with classic opsoclonus-myoclonus syndrome. The investigations revealed neuroblastoma. This case illustrates that transient opsoclonus-myoclonus may occur with neuroblastoma and should not be assumed to be due to viral cause. Thus, a thorough search for occult neuroblastoma should be initiated even if opsoclonus-myoclonus resolves spontaneously.