RT Journal Article
SR Electronic
T1 Protective effect of omega-3 fatty acids in a rat focal cerebral ischemia-reperfusion model
JF Neurosciences Journal
JO Neurosciences (Riyadh)
FD Prince Sultan Military Medical City
SP 198
OP 201
VO 12
IS 3
A1 Kavakli, Ahmet
A1 Kose, Evren
A1 Kus, Ilter
A1 Zararsiz, Ismail
A1 Akpolat, Nusret
A1 Sarsilmaz, Mustafa
YR 2007
UL http://nsj.org.sa/content/12/3/198.abstract
AB OBJECTIVE: To investigate possible neuroprotective effects of dietary supplementation of fish oil in brain ischemia-reperfusion (I/R).METHODS: This investigation took place in the Experimental Research Unit, Firat University, Elazig, Turkey, from January-February 2006. The study was carried out on 12 male Wistar rats; divided into 2 groups: I/R (control) and I/R + omega-3 essential fatty acids (EFA) (experiment). The rats in the I/R group received only ordinary rat food before middle cerebral artery (MCA) occlusion. The I/R + omega-3 EFA group received omega-3 fatty acid daily via intragastric gavage (300 mg/kg Marincap capsule) with normal food before MCA occlusion for 30 days. Structural alterations in the brain tissues were semi-quantitatively analyzed (0: absent, +: slight, ++: moderate, +++: severe).RESULTS: There was evident severe (+++) edema, vacuolization, and eosinophilic degeneration in the I/R group, while only slight (+) edema and eosinophilic degeneration in the I/R + omega-3 EFA group in which no vacuolization was determined. These findings are consistent with the available studies in this field.CONCLUSION: Results from this study indicate the beneficial effects of omega-3 EFA supplementation in prevention of I/R - induced damage in rats.