RT Journal Article
SR Electronic
T1 The effect of nicotine on the recovery of rats receiving anesthesia
JF Neurosciences Journal
JO Neurosciences (Riyadh)
FD Prince Sultan Military Medical City
SP 322
OP 326
VO 12
IS 4
A1 Berrin Isik
A1 Mustafa Arslan
A1 Ozgur Ozsoylar
A1 Yusuf Unal
A1 Cengiz B. Demirel
A1 Nedim cekmen
A1 Omer Kurtipek
YR 2007
UL http://nsj.org.sa/content/12/4/322.abstract
AB OBJECTIVE: To determine the effect of intraperitoneal (ip) nicotine on the recovery of rats receiving general anesthesia compared with placebo.METHODS: The placebo controlled experimental study was conducted in the Faculty of Medicine, Gazi University, Turkey, between April and May 2005. Twenty-one male and 21 female rats were randomly divided into 3 groups. Group C (n=14), comprising a female group CF (n=7), and male group CM (n=7) received ip 0.9% sodium chloride (NaCl), group P (n=14), comprising a female group PF (n=7), and male group PM (n=7) received ip propofol 150 mg/kg, and group NP (n=14), comprising a female group NPF (n=7), and male group NPM (n=7) received 0.4 mg/kg ip nicotine followed by 150 mg/kg propofol after 15 minutes. For the evaluation of recovery period, tail pinch test was used, and for cognitive performance, the radial arm maze test was used.RESULTS: The number of entrances and exits decreased in group P significantly compared to group C (p<0.05), and the decrease in group PF was higher than it was in group PM. Entrance and exit in group NP increased significantly compared to group P (p<0.05). The increase in entrance and exit in group NPF was much higher compared to group NPM. The recovery period in group NP was significantly shorter than in group P (p<0.05).CONCLUSION: The ip administration of nicotine in rats shortens the recovery from propofol anesthesia and improves cognitive performance.