RT Journal Article
SR Electronic
T1 Comparison of meperidine alone with meperidine plus dexmedetomidine for postoperative patient-controlled analgesia
JF Neurosciences Journal
JO Neurosciences (Riyadh)
FD Prince Sultan Military Medical City
SP 117
OP 121
VO 13
IS 2
A1 Nuh T. Altindis
A1 Dilek Karaaslan
A1 Tulay T. Peker
A1 Sadik Ozmen
A1 Mahmut Bulbul
YR 2008
UL http://nsj.org.sa/content/13/2/117.abstract
AB OBJECTIVE: To investigate if the addition of dexmedetomidine to meperidine in a patient-controlled analgesia (PCA) device would reduce postoperative meperidine consumption when compared with meperidine alone.METHODS: Forty patients scheduled for elective abdominal surgery under general anesthesia in Suleyman Demirel University Medical School, Isparta, Turkey between February and September 2006, were randomly allocated into 2 groups. Group I: meperidine 0.25 mg kg-1 intravenous bolus and dexmedetomidine 0.5 mcg kg-1 in 50 ml of saline solution infusion before the end of surgery. Group II: meperidine 0.25 mg kg-1 intravenous bolus and 50 ml of saline solution infusion. In the postanesthesia care unit (PACU) patients in both groups received intravenous meperidine 10 mg with 5-minutes intervals until the patient’s verbal pain score is lower than 2. Patients in both groups received PCA during the 24 hours after surgery (meperidine 5 mg + dexmedetomidine 10 mcg bolus for group I, meperidine 5 mg for group II). The verbal rating score of pain and meperidine requirement is recorded during PACU stay. Meperidine consumption with PCA is recorded until 24 hours postoperatively.RESULTS: Verbal rating score of pain in the PACU was lower in group I than group II (p<0.05). Meperidine consumption was lower in group I than group II during the PACU stay and until 24 hours postoperatively (p<0.01).CONCLUSION: When compared with meperidine PCA, meperidine-dexmedetomidine PCA reduces postoperative meperidine consumption.