PT  - JOURNAL ARTICLE
AU  - Karabekir, Hamit S.
AU  - Balci, Canan
AU  - Aktepe, Fatma
AU  - Tokyol, Cigdem
AU  - Dilek, Husniye
TI  - Which is more effective in reducing secondary brain damage resulting from cyclooxygenase expression following traumatic brain injury: calcium channel blockers or cox inhibitors?
DP  - 2008 Jul 01
TA  - Neurosciences Journal
PG  - 239--243
VI  - 13
IP  - 3
4099  - http://nsj.org.sa/content/13/3/239.short
4100  - http://nsj.org.sa/content/13/3/239.full
SO  - Neurosciences (Riyadh)2008 Jul 01; 13
AB  - OBJECTIVE: To evaluate localizations of cyclooxygenase (COX)-1 and COX-2 following traumatic brain injury (TBI) and the effects of 2 therapeutic agents on COX inhibition. METHODS: Forty rabbits were used in this study for developing a TBI model and divided into 4 groups (n=10) at Afyon Kocatepe University School of Medicine, Afyonkarahisar, Turkey in June 2004. Differential cellular COX-1 and COX-2 protein expression profiles were analyzed following TBI, and the effects of 2 therapeutic agents, indomethacin and nimodipine, on COX inhibition were evaluated immunohistochemically.RESULTS: This study revealed that COX-1 and COX-2 protein expression were significantly increased in vascular endothelial, smooth muscle cells, and CD68+ microglia/macrophages following TBI. Indomethacin inhibited the COX expression in glial cells more than nimodipine, however, both did not affect endothelial COX-1 and COX-2 expression.CONCLUSION: The restricted accumulation of COX-1 at the perilesional area points to an acute inflammatory response and the role of COX-1 in TBI. This study revealed that COX-1 expression should be a pharmacological target following TBI, and COX-2 should also be evaluated in this aspect, and indomethacin is more effective than nimodipine for blocking COX-1.