PT  - JOURNAL ARTICLE
AU  - Bilge, Ugur
AU  - Erol, Kevser
TI  - Effects of sertraline on experimental mouse models of psychosis
DP  - 2012 Jan 01
TA  - Neurosciences Journal
PG  - 32--38
VI  - 17
IP  - 1
4099  - http://nsj.org.sa/content/17/1/32.short
4100  - http://nsj.org.sa/content/17/1/32.full
SO  - Neurosciences (Riyadh)2012 Jan 01; 17
AB  - OBJECTIVE: To study the effects of sertraline on neuroleptic-induced catalepsy, apomorphine-induced climbing behavior, and amphetamine or MK-801-induced locomotor activities in female Swiss albino mice weighing 30-35 g.METHODS: This study was performed in the Department of Pharmacology, Eskisehir Osmangazi University, Eskisehir, Turkey between April 2008 and January 2010. Catalepsy was induced by haloperidol (1 mg/kg intraperitoneally [ip]). Apomorphine (1.5 mg/kg subcutaneously [sc]) was used for studying climbing behavior, and d-amphetamine (30 mg/kg ip) or MK-801 (0.3 mg/kg ip) was used for testing locomotor activities. Eight animals were used in each group. Sertraline (10 mg/kg ip) was injected either acutely, or over 5 days of repeated treatment.RESULTS: Sertraline inhibited catalepsy and climbing behavior when it was used for 5 days in repeated doses, while it augmented amphetamine-induced locomotor activity. It reduced MK-801-induced stereotypic movements, but did not significantly affect amphetamine-induced stereotypic movements when used in a single dose or repeated doses.CONCLUSION: These results suggest that sertraline, a selective serotonin reuptake inhibitor may be a beneficial adjuvant drug during psychosis therapy.