PT  - JOURNAL ARTICLE
AU  - M.Walid Al-Sous
AU  - Saeed A. Bohlega
AU  - M.Zuheir Al-Kawi
AU  - Donald R. McLean
AU  - S.Naveed Ghaus
TI  - Polyradiculopathy. A rare complication of neurobrucellosis
DP  - 2003 Jan 01
TA  - Neurosciences Journal
PG  - 46--49
VI  - 8
IP  - 1
4099  - http://nsj.org.sa/content/8/1/46.short
4100  - http://nsj.org.sa/content/8/1/46.full
SO  - Neurosciences (Riyadh)2003 Jan 01; 8
AB  - Neurobrucellosis is chronic brucellosis affecting the nervous system. It may mimic many neurological diseases but it rarely presents as polyradiculopathy. Brucellar radiculopathy was diagnosed in 6 patients who presented with weakness of the lower extremities. Five patients had lumbar puncture, 4 had magnetic resonance imaging of lumbar spine and 4 had nerve conduction studies. Five patients had areflexia and weakness; one had areflexia with proprioceptive ataxia. All patients had positive Brucella serology; cerebrospinal fluid showed lymphocytic pleocytosis, elevated protein, normal-low glucose; brucella serology was positive in all specimens. Nerve conduction studies showed absent F-wave in 2 patients and polyradiculopathy with secondary motor axonopathy in 2 patients; motor conduction velocity was normal in all. Magnetic resonance imaging with gadolinium injection showed enhancement of lumbar nerve root in 3 patients, and no enhancement in one. All patients improved after treatment with antibiotics and lumbar root enhancement disappeared. Symptoms of myelopathy were unmasked after radiculopathy had resolved in one patient. In endemic areas, brucella infection should be considered in the differential diagnosis of radiculopathy. Radiculopathy is probably due to inflammation of the meninges and the intrathecal portion of the roots. The pathogenesis of myelopathy may involve demyelination as spasticity persists or worsens after radiculopathy improves.