RT Journal Article
SR Electronic
T1 An infant with isolated Lissencephaly
JF Neurosciences Journal
JO Neurosciences (Riyadh)
FD Prince Sultan Military Medical City
SP 250
OP 252
VO 6
IS 4
A1 Jouini, Slim
A1 Al-Awashiz, Abdulla S.
A1 Izoura, George I.
YR 2001
UL http://nsj.org.sa/content/6/4/250.abstract
AB Lissencephaly or agyria is a prototype of disorders of neuronal migration, a rare type of hereditary malformation of the brain, which manifests with smooth cerebral surface, poorly defined sylvian fissures with thickened cerebral cortical mantle. A case of an infant with isolated variety is presented highlighting some of the major associated clinical features, which include profound intellectual impairment, seizures and hypotonia that later evolves to spasticity in the 2nd year of life. Morbidity is usually high and mortality is dependent on associated deficits.