PT  - JOURNAL ARTICLE
AU  - Hamad, Ahmad E.
AU  - Fawzi, Mahmoud E.
TI  - Valproate associated acute pancreatitis
DP  - 2000 Jul 01
TA  - Neurosciences Journal
PG  - 156--158
VI  - 5
IP  - 3
4099  - http://nsj.org.sa/content/5/3/156.short
4100  - http://nsj.org.sa/content/5/3/156.full
SO  - Neurosciences (Riyadh)2000 Jul 01; 5
AB  - There is a definitive association between valproate therapy and acute pancreatitis. More than 50 cases have been reported. Most of the reported cases were mild yet there were a few more cases with higher morbidity and mortality. The risk is higher in patients under 20 years of age, during the first year of therapy, on the patient having encephalopathy or chronic renal failure and on patients with anti-epileptic drug polytherapy. The treatment of pancreatitis is supportive, laparotomy should be avoided. Re-challenge is hazardous and should be avoided.