RT Journal Article
SR Electronic
T1 Valproate associated acute pancreatitis
JF Neurosciences Journal
JO Neurosciences (Riyadh)
FD Prince Sultan Military Medical City
SP 156
OP 158
VO 5
IS 3
A1 Ahmad E. Hamad
A1 Mahmoud E. Fawzi
YR 2000
UL http://nsj.org.sa/content/5/3/156.abstract
AB There is a definitive association between valproate therapy and acute pancreatitis. More than 50 cases have been reported. Most of the reported cases were mild yet there were a few more cases with higher morbidity and mortality. The risk is higher in patients under 20 years of age, during the first year of therapy, on the patient having encephalopathy or chronic renal failure and on patients with anti-epileptic drug polytherapy. The treatment of pancreatitis is supportive, laparotomy should be avoided. Re-challenge is hazardous and should be avoided.