PT  - JOURNAL ARTICLE
AU  - Alnaami, Ibrahim M.
AU  - Al-Nuaimi, Saleem K.
AU  - Senthilselvan, Ambikaipakan
AU  - Murtha, Albert D.
AU  - Walling, Simon
AU  - Mehta, Vivek
AU  - Gourishankar, Sita
TI  - Effectiveness of adjuvant temozolomide treatment in patients with glioblastoma
DP  - 2013 Oct 01
TA  - Neurosciences Journal
PG  - 349--355
VI  - 18
IP  - 4
4099  - http://nsj.org.sa/content/18/4/349.short
4100  - http://nsj.org.sa/content/18/4/349.full
SO  - Neurosciences (Riyadh)2013 Oct 01; 18
AB  - OBJECTIVE: To examine whether adjuvant temozolomide treatment improved glioblastoma patients’ survival in a large Canadian cohort.METHODS: We retrospectively studied 364 glioblastoma patients who received different modalities of treatment in 2 Canadian tertiary care centers in Edmonton and Halifax, Canada, between January 2000 and December 2006. The primary outcome was survival following the treatment protocol.RESULTS: The following variables were associated with an increased risk of death: The hazard risk (HR) of on-gross total resection was 0.50 (95% confidence interval [CI]: 0.39-0.64). The HR for the surgery-only group was 5.2 (95% CI: 3.85-7.06). The standard treatment group (surgery, radiation therapy [RT], and temozolomide) had an HR of 0.52 (95% CI: 0.37-0.74). The HR for patients who presented with seizure or whose presentation included seizures was 0.88 (95% CI: 0.55-0.89). Patient entry into trials had an HR of 0.74 (95% CI: 0.57-0.96). Finally, the HR for age was 1.02 (95% CI: 1.01-1.03) for every extra year.CONCLUSION: Concomitant temozolomide with RT and surgery was associated with longer survival compared with RT with surgery alone. We also found that younger age, surgical resection, seizure presence, and entry into trials are important prognostic factors for longer survival.