PT  - JOURNAL ARTICLE
AU  - Deleu, Dirk
AU  - Northway, Margaret G.
AU  - Hanssens, Yolande
TI  - An evidence-based review of Dopamine receptor agonists in the treatment of Parkinson’s disease
DP  - 2002 Oct 01
TA  - Neurosciences Journal
PG  - 221--231
VI  - 7
IP  - 4
4099  - http://nsj.org.sa/content/7/4/221.short
4100  - http://nsj.org.sa/content/7/4/221.full
SO  - Neurosciences (Riyadh)2002 Oct 01; 7
AB  - Apomorphine and certain ergot alkaloids (bromocriptine, lisuride and pergolide) have been available for several decades; for the last few years, they were joined by newer dopamine agonists (cabergoline, pramipexole and ropinirole) most of them are non-ergolines. Each of these dopamine agonists has its own pharmacological characteristics and occupies a place in the pharmacotherapy of Parkinsons disease. In this evidence-based review, emphasis is put on the clinical efficacy of dopamine agonists in early and advanced Parkinsons disease, and where possible comparative evidence regarding their efficacy and safety is provided. In addition, their clinical pharmacokinetics, adverse effect profiles and most relevant interactions will be summarized.