RT Journal Article
SR Electronic
T1 An evidence-based review of Dopamine receptor agonists in the treatment of Parkinson’s disease
JF Neurosciences Journal
JO Neurosciences (Riyadh)
FD Prince Sultan Military Medical City
SP 221
OP 231
VO 7
IS 4
A1 Dirk Deleu
A1 Margaret G. Northway
A1 Yolande Hanssens
YR 2002
UL http://nsj.org.sa/content/7/4/221.abstract
AB Apomorphine and certain ergot alkaloids (bromocriptine, lisuride and pergolide) have been available for several decades; for the last few years, they were joined by newer dopamine agonists (cabergoline, pramipexole and ropinirole) most of them are non-ergolines. Each of these dopamine agonists has its own pharmacological characteristics and occupies a place in the pharmacotherapy of Parkinsons disease. In this evidence-based review, emphasis is put on the clinical efficacy of dopamine agonists in early and advanced Parkinsons disease, and where possible comparative evidence regarding their efficacy and safety is provided. In addition, their clinical pharmacokinetics, adverse effect profiles and most relevant interactions will be summarized.