PT  - JOURNAL ARTICLE
AU  - Mhiri, Chokri
AU  - Choyakh, Fakher
AU  - Ben Hmida, Mohamed
AU  - Feki, Imed
AU  - Ben Messaud, Mounir
AU  - Zouari, Nouri
TI  - Trigeminal somatosensory evoked potentials in trichloroethylene-exposed workers
DP  - 2004 Apr 01
TA  - Neurosciences Journal
PG  - 102--107
VI  - 9
IP  - 2
4099  - http://nsj.org.sa/content/9/2/102.short
4100  - http://nsj.org.sa/content/9/2/102.full
SO  - Neurosciences (Riyadh)2004 Apr 01; 9
AB  - OBJECTIVE: To assess the value of trigeminal somatosensory evoked potentials (TSEP) in evaluating toxicity of trichloroethylene to the trigeminal nerve.METHODS: Trichloroethylene (TCE), an excellent fat solvent largely used in industry, has a neurotoxic effect particularly on the trigeminal nerve. In March 2002, several TCE-exposed workers presented to Habib Bourguiba University Hospital, Sfax, Tunisia, for burned or numbness of the face. Twenty-three workers manipulating TCE underwent clinical, biological and toxicological assessment. Neurophysiologic study consisted of the measurement of the latencies and the amplitudes of TSEP in 23 exposed workers and 23 controls.RESULTS: Abnormal TSEP were observed in 6 workers with clinical evidence of trigeminal involvement and in 9 asymptomatic workers. We observed a significant positive correlation between duration of exposure and the N2 latency (r=0.5, p<0.01) and P2 latency (r=0.6, p<0.02). The sensitivity of TSEP was 65% and the specificity was 100%.CONCLUSION: Trigeminal somatosensory evoked potentials are a useful tool in the diagnosis and management of chronic neurological complications of TCE intoxication. Since alterations of TSEP precede clinical symptoms, trigeminal nerve involvement can be demonstrated at the infra-clinical stage.