PT  - JOURNAL ARTICLE
AU  - Abuhamed, Mutasem M.
AU  - Bo, Xiao
AU  - Zhi, Song
TI  - Experimental epileptic discharge can be transmitted between 2 brains in rats
DP  - 2009 Apr 01
TA  - Neurosciences Journal
PG  - 128--130
VI  - 14
IP  - 2
4099  - http://nsj.org.sa/content/14/2/128.short
4100  - http://nsj.org.sa/content/14/2/128.full
SO  - Neurosciences (Riyadh)2009 Apr 01; 14
AB  - OBJECTIVE: To identify whether epileptic discharges can be conducted out of the brain according to the principle of a lightning rod.METHODS: This experimental study was conducted at Central South University, Xiangya Hospital, Hunan, China between 2005 and 2008. Eighty Sprague-Dawley rats were implanted with intra hippocampus and intra frontal lobe electrodes, and randomized to 3 groups: (A) a group that was kindled via stimulation of intra-hippocampus injection of penicillin, (B) a group that was stimulated via a copper wire connected to the intra-hippocampus electrodes of group A, (C) a group composed of non-stimulated, control rats. The behavioral changes and epileptiform activity were assessed by both Racine Grade and electrocorticogram (ECoG).RESULTS: The intrahippocampal ECoG recordings were coincident with clinical seizures, electrographic seizures occurred not only in the injected hippocampus group A rats, but also in the connected group B rats. However, there were no visible seizures or ECoG burst at any time in group C rats.CONCLUSION: Epileptic discharge can be conducted out of the brain, which may open new therapeutic approaches for epilepsy.