RT Journal Article
SR Electronic
T1 Experimental epileptic discharge can be transmitted between 2 brains in rats
JF Neurosciences Journal
JO Neurosciences (Riyadh)
FD Prince Sultan Military Medical City
SP 128
OP 130
VO 14
IS 2
A1 Abuhamed, Mutasem M.
A1 Bo, Xiao
A1 Zhi, Song
YR 2009
UL http://nsj.org.sa/content/14/2/128.abstract
AB OBJECTIVE: To identify whether epileptic discharges can be conducted out of the brain according to the principle of a lightning rod.METHODS: This experimental study was conducted at Central South University, Xiangya Hospital, Hunan, China between 2005 and 2008. Eighty Sprague-Dawley rats were implanted with intra hippocampus and intra frontal lobe electrodes, and randomized to 3 groups: (A) a group that was kindled via stimulation of intra-hippocampus injection of penicillin, (B) a group that was stimulated via a copper wire connected to the intra-hippocampus electrodes of group A, (C) a group composed of non-stimulated, control rats. The behavioral changes and epileptiform activity were assessed by both Racine Grade and electrocorticogram (ECoG).RESULTS: The intrahippocampal ECoG recordings were coincident with clinical seizures, electrographic seizures occurred not only in the injected hippocampus group A rats, but also in the connected group B rats. However, there were no visible seizures or ECoG burst at any time in group C rats.CONCLUSION: Epileptic discharge can be conducted out of the brain, which may open new therapeutic approaches for epilepsy.