PT  - JOURNAL ARTICLE
AU  - Alkhenizan, Abdullah H.
AU  - Al-Omran, Mohammed A.
TI  - The role of vitamin E in the prevention of coronary events and stroke. Meta-analysis of randomized controlled trials
DP  - 2005 Jan 01
TA  - Neurosciences Journal
PG  - 23--29
VI  - 10
IP  - 1
4099  - http://nsj.org.sa/content/10/1/23.short
4100  - http://nsj.org.sa/content/10/1/23.full
SO  - Neurosciences (Riyadh)2005 Jan 01; 10
AB  - Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in the world. Vitamin E as an anti-oxidant vitamin, was suggested to have a role in the prevention of CVD. We did a meta-analysis, using the Cochrane Group Methodology, of all available randomized controlled trials (RCTs) to evaluate the role of vitamin E in the prevention of CVD. Nine studies met inclusion criteria, including 80,645 participants. Vitamin E supplementation was not associated with a reduction in total mortality or total CVD mortality, but it was associated with a small statistically significant reduction in non-fatal myocardial infarction in patients with pre-existing coronary artery disease. Prophylactic use of vitamin E in doses ranging between 50-800 IU was not associated with any increase in the incidence of serious side effects.