PT  - JOURNAL ARTICLE
AU  - Jacob P. Chacko
AU  - Shanmugakonar Muralitharan
AU  - Alia Al-Ansari
AU  - Khalsa Al-Kharusi
AU  - Abdullah Al-Asmi
AU  - Chand R. Pratap
AU  - Riad Bayoumi
TI  - Trinucleotide repeat analysis of spinocerebellar ataxia patients in Oman
DP  - 2005 Jan 01
TA  - Neurosciences Journal
PG  - 61--63
VI  - 10
IP  - 1
4099  - http://nsj.org.sa/content/10/1/61.short
4100  - http://nsj.org.sa/content/10/1/61.full
SO  - Neurosciences (Riyadh)2005 Jan 01; 10
AB  - OBJECTIVE: To explore the profile of cytosine/adenine/guanine (CAG) repeat expansion in Omani spinocerebellar ataxia (SCA) patients.METHODS: Ten SCA patients attending the Sultan Qaboos University Hospital Neurologic clinics, Al-Khoud, Oman in the 3 years starting from January 2000 were recruited for this study. Genomic DNA was extracted from peripheral blood samples and CAG repeat expansion analysis was carried out by polymerase chain reaction and sequencing, when required.RESULTS: The CAG triplet repeats leading to polyglutamine expansion and neurodegeneration are seen in spinocerebellar ataxias 1, 2, 3, 6, 7 and 17. By using primers for SCA 1, 2, 3 and 7, we found the repeats were in the normal range and triplet repeats do not seem to be a common cause for ataxia in Oman.CONCLUSION: Spinocerebellar ataxia in Oman has the normal range of CAG repeats for the commonly found SCA1, SCA2, SCA3 and SCA7.