RT Journal Article
SR Electronic
T1 Isoniazid intoxication. Light and electron microscopic findings in muscle and sural nerve biopsies
JF Neurosciences Journal
JO Neurosciences (Riyadh)
FD Prince Sultan Military Medical City
SP 230
OP 231
VO 10
IS 3
A1 Abu-Ghalyun, Younes
YR 2005
UL http://nsj.org.sa/content/10/3/230.abstract
AB This study indicates the cellular and ultrastructural changes of the thigh muscle and sural nerve biopsies of a patient intoxicated as a result of isoniazid intake for tuberculosis treatment. The observation of the relative degradation of myelination and fibre type II groups was apparent. The regular concentric layers of the myelin sheath were destroyed. There was a consistent increase in irregular vacuolization and membranous structures in the axon and the cytoplasm of the Schwan cells. It is concluded that poisoning cannot be attributed solely to the axonal degradation but also to the direct toxic effect of the drug.