RT Journal Article
SR Electronic
T1 Mechanisms and regulation of neurotrophin synthesis and secretion
JF Neurosciences Journal
JO Neurosciences (Riyadh)
FD Prince Sultan Military Medical City
SP 306
OP 313
DO 10.17712/nsj.2016.4.20160080
VO 21
IS 4
A1 Al-Qudah, Mohammad A.
A1 Al-Dwairi, Ahmed
YR 2016
UL http://nsj.org.sa/content/21/4/306.abstract
AB Neurotrophins are secreted proteins that are synthesized as pre-pro-neurotrophins on the rough endoplasmic reticulum, which are subsequently processed and then secreted as mature proteins. During synthesis, neurotrophins are sorted in the trans-Golgi apparatus into 2 pathways of secretion; the constitutive and the regulated pathways. Neurotrophins in the constitutive pathway are secreted cautiously without any trigger, while in the regulated pathway of secretion an external stimulus elevates the calcium concentration intracellularly leading to neurotrophin release. The regulation of sorting and secretion of neurotrophins is critical for several processes in the body, such as synaptic plasticity, neurodegenerative disorders, demyelination disease, and inflammation. The purpose of this review is to summarize the current mechanisms of neurotrophin sorting and secretion.