PT  - JOURNAL ARTICLE
AU  - Khaki, Mohsen
AU  - Ghazavi, Ali
AU  - Ghasami, Keyvan
AU  - Rafiei, Mohammad
AU  - Payani, Mohammah-Ali
AU  - Ghaznavi-Rad, Ehsanollah
AU  - Mosayebi, Ghasem
TI  - Evaluation of viral antibodies in Iranian multiple sclerosis patients
DP  - 2011 Jul 01
TA  - Neurosciences Journal
PG  - 224--228
VI  - 16
IP  - 3
4099  - http://nsj.org.sa/content/16/3/224.short
4100  - http://nsj.org.sa/content/16/3/224.full
SO  - Neurosciences (Riyadh)2011 Jul 01; 16
AB  - OBJECTIVE: To evaluate the viral antibodies in new Iranian multiple sclerosis (MS) patients.METHODS: In a cross-sectional study, sera from 61 MS patients and 60 healthy individuals were collected from January 2009 to March 2010 in the Immunology Department of Arak University of Medical Sciences, Arak, Iran, and examined for the presence of the anti-Epstein-Barr virus (EBV), human herpes virus 6 (HHV-6), measles, mumps, and para-influenza viruses IgG and IgM using an enzyme-linked immunosorbent assay or immunofluorescence.RESULTS: There were significant differences between the MS patients and the healthy individuals (controls) in the seroprevalence of anti-HHV-6 IgM (odds ratio [OR]=4.3, 95% confidence interval [CI]=2-9.3, p=0.001); anti-HHV-6 IgG (OR=2, 95% CI=1-4, p=0.04); anti-measles IgM (OR=3.2, 95% CI=1.5-6.9, p=0.002); and the anti-mumps IgM (OR=4.1, 95% CI=1.9-8.8, p=0.0001) and IgG (OR=9.5, 95% CI=3-29.6, p=0.0001). Almost all MS patients and the control individuals were negative to EBV and parainfluenza IgM.CONCLUSION: These results confirm an association between the incidence of MS and the antibodies to HHV-6 and the measles and mumps viruses, and show induction of a primary immune response (IgM), or virus reactivation, in MS patients. These viruses may have an important role in development of MS as an initial trigger in this geographical area.