RT Journal Article
SR Electronic
T1 Pre-training Catechin gavage prevents memory impairment induced by intracerebroventricular streptozotocin in rats
JF Neurosciences Journal
JO Neurosciences (Riyadh)
FD Prince Sultan Military Medical City
SP 225
OP 229
DO 10.17712/nsj.2015.3.20140440
VO 20
IS 3
A1 Marzieh Zamani
A1 Kambiz Rohampour
A1 Maryam Zeraati
A1 Narges Hosseinmardi
A1 Mostafa M. Kazemian
YR 2015
UL http://nsj.org.sa/content/20/3/225.abstract
AB Objective: To evaluate the effects of Catechin (CAT) on memory acquisition and retrieval in the animal model of sporadic alzheimer’s disease (sAD) induced by intracerebroventricular (icv) injection of streptozotocin (STZ) in passive avoidance memory test.Methods: Thirty adult rats were divided into 5 experimental groups (n=6). Animals were treated by icv saline/STZ (3 mg/kg) injection at day one and 3 after cannulation. The STZ+CAT group received 40 mg/kg CAT by daily gavages for 10 days, after icv STZ treatment and before training. The step-through latency (STL) and time spent in the dark compartment (TDC) were evaluated to examine the memory acquisition and retrieval. All tests were performed in Qom University of Medical Sciences, Qom, Iran, from April to December 2013.Results: The STZ treatment significantly decreased STL and increased the number of entries to the dark compartment on the training day. It also increased TDC, on day one and 7 after training. Pre-training gavage of CAT reversed the STL significantly (p=0.027). The CAT treatment also decreased the TDC in both early and late retrieval, in respect to STZ group.Conclusion: This data suggests that CAT as an antioxidant could improve both memory acquisition and retrieval in the animal model of sAD.