PT  - JOURNAL ARTICLE
AU  - Tohid, Hassaan
TI  - Anti-glutamic acid decarboxylase antibody positive neurological syndromes
AID  - 10.17712/nsj.2016.3.20150596
DP  - 2016 Jul 01
TA  - Neurosciences Journal
PG  - 215--222
VI  - 21
IP  - 3
4099  - http://nsj.org.sa/content/21/3/215.short
4100  - http://nsj.org.sa/content/21/3/215.full
SO  - Neurosciences (Riyadh)2016 Jul 01; 21
AB  - A rare kind of antibody, known as anti-glutamic acid decarboxylase (GAD) autoantibody, is found in some patients. The antibody works against the GAD enzyme, which is essential in the formation of gamma aminobutyric acid (GABA), an inhibitory neurotransmitter found in the brain. Patients found with this antibody present with motor and cognitive problems due to low levels or lack of GABA, because in the absence or low levels of GABA patients exhibit motor and cognitive symptoms. The anti-GAD antibody is found in some neurological syndromes, including stiff-person syndrome, paraneoplastic stiff-person syndrome, Miller Fisher syndrome (MFS), limbic encephalopathy, cerebellar ataxia, eye movement disorders, and epilepsy. Previously, excluding MFS, these conditions were called ‘hyperexcitability disorders’. However, collectively, these syndromes should be known as “anti-GAD positive neurological syndromes.” An important limitation of this study is that the literature is lacking on the subject, and why patients with the above mentioned neurological problems present with different symptoms has not been studied in detail. Therefore, it is recommended that more research is conducted on this subject to obtain a better and deeper understanding of these anti-GAD antibody induced neurological syndromes.