PT  - JOURNAL ARTICLE
AU  - Al-Quliti, Khalid W.
AU  - Assaedi, Ekhlas S.
TI  - New advances in prevention of migraine
AID  - 10.17712/nsj.2016.3.20150506
DP  - 2016 Jul 01
TA  - Neurosciences Journal
PG  - 207--214
VI  - 21
IP  - 3
4099  - http://nsj.org.sa/content/21/3/207.short
4100  - http://nsj.org.sa/content/21/3/207.full
SO  - Neurosciences (Riyadh)2016 Jul 01; 21
AB  - Despite being one of the most common disabling primary headaches, migraine continues to be under-diagnosed and under-treated. A migraine challenges not only the patient suffering from the migraine, but also physicians; especially in recognizing candidates for prophylaxis and selecting the appropriate preventive medication. Recently, there have been major advances in the diagnosis and treatment of migraine, with different guidelines of migraine management across the world. Here, we review migraine’s abortive and prophylactic medications, based on their pharmacologic category, citing their recommended doses, efficacy, and side effects. Additionally, we highlight the prophylactic treatment of specific patient populations and present suggested treatment approaches in view of recent international treatment guidelines that consider factors other than drug efficacy when choosing the optimal preventive therapy. Finally, we introduce drugs in different stages of development, which have novel mechanisms of action or have new therapeutic targets.