RT Journal Article
SR Electronic
T1 P50 variations in Behcet’s patients without neurologic findings
JF Neurosciences Journal
JO Neurosciences (Riyadh)
FD Prince Sultan Military Medical City
SP 50
OP 52
VO 12
IS 1
A1 Meral Ascioglu
A1 Mustafa Arslan
A1 Cem Suer
A1 Ozcan Ascioglu
A1 Cigdem Ozesmi
A1 Murat Borlu
A1 Abdulhakim Coskun
A1 Ali S. Gonul
A1 Emel Koseoglu
YR 2007
UL http://nsj.org.sa/content/12/1/50.abstract
AB OBJECTIVE: In the present study, subclinical lesion involvement was investigated using the P50 component in Behcet’s patients without neurological manifestation.METHODS: We performed this clinical research in Erciyes University, Faculty of Medicine between December 2000 and November 2001. The studies were carried out on 18 Behcet’s patients without neurologic findings and 18 volunteers for control. Standard Ag/AgCl electrodes in plastic cups were used for monopolar EEG derivations. They were attached with electrode paste and tape at the Cz (vertex) according to the 10-20 system. The auditory stimuli were delivered in pairs. The P50 waves, which may be taken from approximately 50 msec from the stimuli, were collected by computer system. Amplitudes and latencies of the P50 components were measured in the same system.RESULTS: This study showed that the suppression of P50 responses performed by the test stimuli, was significantly more decreased in Behcet’s patients than the control subjects.CONCLUSION: The decrease of the suppression of the auditory P50 response to repeated stimuli reflects a deficit in the central nervous system’s ability, such as attention, cognition, and sensory input in Behcet’s patients and can be used as a neurophysiological marker in subclinical lesions in these patients.