RT Journal Article
SR Electronic
T1 Opioid receptors are not involved in the increase of the nociceptive threshold induced by aerobic exercise
JF Neurosciences Journal
JO Neurosciences (Riyadh)
FD Prince Sultan Military Medical City
SP 33
OP 37
VO 19
IS 1
A1 Galdino, Giovane
A1 Romero, Thiago
A1 Andrade, Ian
A1 Duarte, Igor
A1 Perez, Andrea
YR 2014
UL http://nsj.org.sa/content/19/1/33.abstract
AB OBJECTIVE: To investigate the involvement of opioid receptors in antinociception induced by different aerobic exercise protocols in rats.METHODS: This experimental study, conducted in the Federal University of Minas Gerais, Belo Horizonte, Brazil from November 2011 to May 2012, included 60 female Wistar rats, divided into 10 groups of 6 animals per group. The rats were subjected to different aerobic exercise protocols: acute, cardiac stress, eccentric, and training. The nociceptive threshold was measured by the paw-withdrawal test. To investigate the involvement of the endogenous opioids system, the non-selective opioid receptor antagonist naloxone (5 mg/kg) was administered subcutaneously before the beginning of the exercise.RESULTS: All exercise protocols increased the nociceptive threshold for 15 minutes. The naloxone pre-treatment did not alter the antinociception induced by aerobic exercise protocols.CONCLUSION: The endogenous opioids system did not participate in the antinociceptive effect produced by the aerobic exercise protocols.