RT Journal Article
SR Electronic
T1 Neuroinflammation. Contemporary anti-inflammatory treatment approaches
JF Neurosciences Journal
JO Neurosciences (Riyadh)
FD Prince Sultan Military Medical City
SP 87
OP 92
VO 19
IS 2
A1 Md. Mamun Al-Amin
A1 Hasan M. Reza
YR 2014
UL http://nsj.org.sa/content/19/2/87.abstract
AB We investigated the idea of possible anti-inflammatory treatment approaches for inflammatory disorders in the CNS. The articles used for this review were searched through PubMed, PsycINFO, and Google scholar and published between January 2000 and July 2013. The CNS has its own type of defensive mechanism. The crosstalk between neurons and the immune system take place via small molecules called cytokines that are secreted from glial cells. Previous study suggested that the imbalance of cytokines facilitates the development of CNS disorders. For instance, the interleukin-6 level is raised in the astrocyte cell during depressive episodes, while axons are damaged by the activated lymphocytes and microglia in multiple sclerosis. Several studies demonstrated that cytokines and inflammatory compounds are closely linked to neuropsychiatric and neurodegenerative disorders. Here, we have accumulated and summarized evidence from those papers that support the anti-inflammatory treatment options for inflammatory CNS disorders.