PT - JOURNAL ARTICLE AU - Gelan M. Salem AU - Wafik M. El-Sheik AU - Basma G. El-shanawany AU - Khaled H. Afifi TI - Low versus standard dose intravenous alteplase in the treatment of acute ischemic stroke in Egyptian patients AID - 10.17712/nsj.2021.2.20200148 DP - 2021 Apr 01 TA - Neurosciences Journal PG - 179--185 VI - 26 IP - 2 4099 - http://nsj.org.sa/content/26/2/179.short 4100 - http://nsj.org.sa/content/26/2/179.full SO - Neurosciences (Riyadh)2021 Apr 01; 26 AB - Objectives: To assess low dose altepase outcome and safety in comparison with a standard-dose regimen for acute ischemic stroke treatment in Egyptian patients.Materials: An observational prospective cohort non-randomized single blinded study was carried out during the period from November 2017 to December 2018. Eighty Egyptian acute ischemic stroke patients, all eligible for intravenous alteplase, were subdivided into 2 groups (40 patients in each group). Patients were thrombolysed at a dose of 0.6 mg/kg in the first group and 0.9 mg/kg in the second group. Both groups were compared in regard to safety and outcome. Safety was expressed by the rate of symptomatic intracranial hemorrhage (SICH) and 3 months mortality, while outcome was expressed by favorable outcomes at three months (modified Rankin Scale [mRS] of 0 to 2).Results: In the first group, 69.2% (n=27) achieved favorable outcomes at 90 days compared with 64.1% (n=25) in the second group (p=0.631). Ninety-day mortality was 5% (n=2) in the first group versus 2.5% (n=1) in the second group (p=0.556). Symptomatic intracranial hemorrhage was noted in 3 patients in the second group and zero patients in the first group (p=0.077).Conclusion: Low-dose alteplase could be a practical alternative for Egyptian populations with acute ischemic stroke especially in 3 to 4.5 hours window.