PT  - JOURNAL ARTICLE
AU  - Berkol, Tonguc D.
AU  - Balcioglu, Yasin H.
AU  - Kirlioglu, Simge S.
AU  - Ozarslan, Zengibar
AU  - Islam, Serkan
AU  - Ozyildirim, Ilker
TI  - Clinical characteristics of antidepressant use and related manic switch in bipolar disorder
AID  - 10.17712/nsj.2019.1.20180008
DP  - 2019 Jan 01
TA  - Neurosciences Journal
PG  - 45--52
VI  - 24
IP  - 1
4099  - http://nsj.org.sa/content/24/1/45.short
4100  - http://nsj.org.sa/content/24/1/45.full
SO  - Neurosciences (Riyadh)2019 Jan 01; 24
AB  - Objectives: To examine the association between clinical and treatment characteristics and antidepressants (AD)-induced manic switch in bipolar disorder (BD).Methods: Total of 238 euthymic BD patients, who had been followed-up for at least 6 months at the outpatient clinic of Haseki Training and Research Hospital in istanbul, Turkey, were enrolled in this cross-sectional study in 2016. Semi-structured data form, the mood chart, and the mirror-designated assessment were applied to all subjects. The files of the patients were retrospectively reviewed and the patients using ADs were compared as AD-monotherapy (AD-m) and AD-combination (AD-c) groups, then divided into 2 subgroups according to the presence/absence of manic switch under AD treatment.Results: Fifty eight (47.15%) patients out of 123 who received ADs at least once had experienced a manic switch under AD treatment. The rate of manic switch in AD-m patients was significantly higher than the AD-c group. Independent from being monotherapy or combined treatment, AD use longer than 12 months was negatively associated with the occurrence of manic switch.Conclusion: Our study suggests that the risk of manic switch is especially prominent in the first months of AD use. Antidepressants use in combining it with a mood stabilizers (MS) may not be adequate in preventing switches in shorter terms. However, in longer term uses addition of MS to ADs may decrease the risk of switches.