RT Journal Article
SR Electronic
T1 <em>COMT</em>Val158Met polymorphism is associated with ecstasy (MDMA)-induced psychotic symptoms in the Turkish population
JF Neurosciences Journal
JO Neurosciences (Riyadh)
FD Prince Sultan Military Medical City
SP 24
OP 30
DO 10.17712/nsj.2022.1.20210045
VO 27
IS 1
A1 Hasan Mervan Aytac
A1 Yasemin Oyaci
A1 Pinar Cetinay Aydin
A1 Mustafa Pehlivan
A1 Sacide Pehlivan
YR 2022
UL http://nsj.org.sa/content/27/1/24.abstract
AB Objectives: To investigate catechol-O-methyltransferase (COMT) Val158Met gene polymorphism in MDMA use disorder (MUD) by comparing genotype distributions between MUD patients and healthy controls considering clinical parameters.Methods: Eighty-two MUD patients’ were consecutively admitted to the outpatient psychiatry clinic in May 2019-January 2020, and 95 healthy volunteers were included in the case-control study. We used the polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) to determine COMT Val158Met polymorphism.Results: The COMT Val158Met genotype distribution and allele frequencies of the MUD patient group were significantly different from the healthy control group. The Met/Met genotype (OR: 2.692; 95% Cl: 1.272-5.698; p=0.008) and Met allele frequencies (OR: 1.716; 95% Cl: 1.118-2.633; p=0.013) were significantly higher in the control group than in MUD patients. When the COMT Val158Met genotype and allele frequency distributions were compared between 2 groups according to the psychotic symptoms in the MUD patient group, the COMT Val158Met genotype distributions were significantly different between the groups of patients. The percentage of patients with the Val/Val genotype was significantly lower in MUD patients with a psychotic symptom than the MUD patients without a psychotic symptom (OR: 2.625; 95% Cl: 1.069–6.446; p=0.033).Conclusion: The COMT Val158Met gene polymorphism was found to be related to the MUD-diagnosed Turkish patients and MDMA-induced psychotic symptoms.