<?xml version='1.0' encoding='UTF-8'?><xml><records><record><source-app name="HighWire" version="7.x">Drupal-HighWire</source-app><ref-type name="Journal Article">17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Al-Wutayd, Osama A.</style></author><author><style face="normal" font="default" size="100%">Mohamed, Ashri G.</style></author><author><style face="normal" font="default" size="100%">Saeedi, Jameelah A.</style></author><author><style face="normal" font="default" size="100%">Alotaibi, Hessa S.</style></author><author><style face="normal" font="default" size="100%">Al Jumah, Mohammed A.</style></author></authors><secondary-authors></secondary-authors></contributors><titles><title><style face="normal" font="default" size="100%">Association between obesity during different age periods and multiple sclerosis in Saudi Arabia: A multicenter case–control study</style></title><secondary-title><style face="normal" font="default" size="100%">Neurosciences Journal</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2022-04-01 00:00:00</style></date></pub-dates></dates><pages><style  face="normal" font="default" size="100%">87-93</style></pages><doi><style  face="normal" font="default" size="100%">10.17712/nsj.2022.2.20210121</style></doi><volume><style face="normal" font="default" size="100%">27</style></volume><issue><style face="normal" font="default" size="100%">2</style></issue><abstract><style  face="normal" font="default" size="100%">Objectives: To determine whether body size in different age periods is associated with an increased risk of MS in Saudi Arabia.Methods: This study included 307 MS patients and 307 healthy controls from clinics and hospital wards in three cities (Riyadh, Jeddah, and Dammam) in Saudi Arabia (2016-2017). We used Stunkard’s standard body silhouettes to determine the participants’ body sizes (from 1 to 9) during different age periods (school levels). We calculated adjusted odds ratios (AORs) and 95% confidence intervals (CIs) and performed multivariable analysis adjusted for age and gender.Results: Large body sizes (silhouettes 6–9) and body size 5 during intermediate school were associated with an increased risk of MS (AOR: 3.75, 95% CI: 1.10–12.78 and AOR: 3.75, 95% CI: 1.41–10, respectively). The smallest body size (1) during intermediate school was associated with a lower risk of MS (AOR: 0.39, 95% CI: 0.17–0.90) compared to body size 3.Conclusion: Overweight and obesity during the intermediate school period (ages 13–15 years) are associated with an increased risk of MS, particularly among females.</style></abstract></record></records></xml>