@article {Alanazi59, author = {Ghalib M. Alanazi and Turki F. ALOsaimi and Ali H. Alwadei and Ali D. Al-Otaibi and Lamya A. Jad and Alawi A. Al-Attas}, title = {Efficacy and safety of corpus callosotomy versus vagus nerve stimulation as long-term adjunctive therapies in children with Lennox{\textendash}Gastaut syndrome}, volume = {27}, number = {2}, pages = {59--64}, year = {2022}, doi = {10.17712/nsj.2022.2.20210135}, publisher = {Neurosciences Journal}, abstract = {Objectives: To compare the efficacy and safety of corpus callosotomy versus vagus nerve stimulation (VNS) as long-term adjunctive therapies in children with Lennox{\textendash}Gastaut syndrome.Methods: This retrospective study was conducted in King Fahad Medical City between 2010 and 2019. The authors identified and followed 9 patients with Lennox{\textendash}Gastaut syndrome (LGS) who underwent corpus callosotomy or VNS implantation for at least 12 months; seizure frequency and major complications were monitored. Five patients with a mean age of 10.8{\textpm}1.3 years had corpus callosotomy, and 4 patients with a mean age of 13.8{\textpm}3.9 years were implanted with VNS stimulators.Results: Reduction in seizure frequency was achieved in all 5 patients who underwent corpus callosotomy, with greater than 75\% seizure reduction in more than 50\% in one, and greater than 25\% in 2 respectively. However, in those implanted with VNS, 2 (50\%) patients achieved a reduction in seizure frequency of greater than 75\% and 2 (50\%) greater than 25\%, respectively. No significant difference was observed between the 2 treatment groups. One patient who underwent corpus callosotomy suffered cerebrospinal fluid leakage, and swallowing difficulties in one patient who underwent VNS.Conclusion: Both corpus callosotomy and VNS are safe and effective as adjunctive treatments for LGS patients.}, URL = {https://nsj.org.sa/content/27/2/59}, eprint = {https://nsj.org.sa/content/27/2/59.full.pdf}, journal = {Neurosciences Journal} }