PT  - JOURNAL ARTICLE
AU  - Al-Dorzi, Hasan M.
AU  - Alruwaita, Abdullah A.
AU  - Marae, Bothaina O.
AU  - Alraddadi, Bushra S.
AU  - Tamim, Hani M.
AU  - Ferayan, Ahmad
AU  - Arabi, Yaseen M.
TI  - Incidence, risk factors and outcomes of seizures occurring after craniotomy for primary brain tumor resection
AID  - 10.17712/nsj.2017.2.20160570
DP  - 2017 Apr 01
TA  - Neurosciences Journal
PG  - 107--113
VI  - 22
IP  - 2
4099  - http://nsj.org.sa/content/22/2/107.short
4100  - http://nsj.org.sa/content/22/2/107.full
SO  - Neurosciences (Riyadh)2017 Apr 01; 22
AB  - Objective: To determine the incidence, risk factors and outcomes of early post-craniotomy seizures.Method: This was a retrospective cohort study of all patients who underwent craniotomy for primary brain tumor resection (2002-2011) and admitted postoperatively to the intensive care unit. The patients were divided into 2 groups depending on the occurrence of seizures within 7 days.Results: One-hundred-ninety-three patients were studied: 35.8% had preoperative seizure history and 16.6% were on prophylactic antiepileptic drugs (AEDs). Twenty-seven (14%) patients had post-craniotomy seizures. The tumors were mostly meningiomas (63% for the post-craniotomy seizures group versus 58.1% for the other group; p=0.63) and supratentorial (92.6% for the post-craniotomy seizures versus 78.4% for the other group, p=0.09) with tumor diameter=3.7±1.5 versus 4.2±1.6 cm, (p=0.07). One (3.1%) of the 32 patients on prophylactic AEDs had post-craniotomy seizures compared with 12% of the 92 patients not receiving AEDs preoperatively (p=0.18). On multivariate analysis, predictors of post-craniotomy seizures were preoperative seizures (odds ratio, 2.62; 95% confidence interval, 1.12-6.15) and smaller tumor size <4 cm (odds ratio, 2.50; 95% confidence interval, 1.02-6.25). Post-craniotomy seizures were not associated with increased morbidity or mortality.Conclusion: Early seizures were common after craniotomy for primary brain tumor resection, but were not associated with worse outcomes. Preoperative seizures and smaller tumor size were independent risk factors.