PT  - JOURNAL ARTICLE
AU  - Abdullahi, Aminu T.
AU  - Adamu, Lawan H.
TI  - Neuronal network models of epileptogenesis
AID  - 10.17712/nsj.2017.2.20160455
DP  - 2017 Apr 01
TA  - Neurosciences Journal
PG  - 85--93
VI  - 22
IP  - 2
4099  - http://nsj.org.sa/content/22/2/85.short
4100  - http://nsj.org.sa/content/22/2/85.full
SO  - Neurosciences (Riyadh)2017 Apr 01; 22
AB  - Epilepsy is a chronic neurological condition, following some trigger, transforming a normal brain to one that produces recurrent unprovoked seizures. In the search for the mechanisms that best explain the epileptogenic process, there is a growing body of evidence suggesting that the epilepsies are network level disorders. In this review, we briefly describe the concept of neuronal networks and highlight 2 methods used to analyse such networks. The first method, graph theory, is used to describe general characteristics of a network to facilitate comparison between normal and abnormal networks. The second, dynamic causal modelling, is useful in the analysis of the pathways of seizure spread. We concluded that the end results of the epileptogenic process are best understood as abnormalities of neuronal circuitry and not simply as molecular or cellular abnormalities. The network approach promises to generate new understanding and more targeted treatment of epilepsy.