RT Journal Article
SR Electronic
T1 The relationship between serum cystatin C levels and Hughes motor scale in Guillain-Barré syndrome
JF Neurosciences Journal
JO Neurosciences (Riyadh)
FD Prince Sultan Military Medical City
SP 175
OP 180
DO 10.17712/nsj.2022.3.20210126
VO 27
IS 3
A1 Mengying Chen
A1 Jinming Shi
A1 Jiaxin Fan
A1 Hong Sun
A1 Qingling Yao
A1 Xiaodong Zhang
A1 Shuang Du
A1 Huiyang Qu
A1 Yuxuan Cheng
A1 Shuyin Ma
A1 Meijuan Zhang
A1 Shuqin Zhan
YR 2022
UL http://nsj.org.sa/content/27/3/175.abstract
AB Objectives: To study the clinical features of Guillain–Barré syndrome (GBS) and the relationship between serum cystatin C (cysC) levels and Hughes motor scale (HMS) in GBS.Methods: One hundred and one GBS patients between January 2017 and January 2020 were reviewed retrospectively. Their epidemiological characteristics, clinical manifestations and auxiliary examinations were assessed. The HMS was used to measure the peak deficit. The influencing factors of GBS severity were analyzed by univariate and multivariate analyses.Results: The serum cysC levels were significantly higher in the severe group than in the mild group [0.98 (0.85-1.20) vs. 0.81 (0.76-0.95), p=0.004], and there was a positive correlation between serum cysC levels and HMS in GBS patients (r=0.376, p=0.001). On multivariate analysis, respiratory muscle palsy (p=0.003), time to peak deficit (p=0.017), serum cysC (p=0.045) and hyponatremia (p=0.015) were independent risk factors for a poor functional outcome (HMS>3). Combining serum cysC and respiratory muscle palsy was more valuable for assessing disease severity than respiratory muscle palsy alone (AUC 0.863 vs. 0.787, p=0.001).Conclusion: Serum cysC was an independent risk factor in GBS, and positively correlated with HMS. It might be used to assess the severity of GBS with other negative prognostic factors.