PT  - JOURNAL ARTICLE
AU  - Zhao, Yongrui
AU  - Chen, Yidong
AU  - Wang, Leiming
AU  - Gao, Ying
AU  - Xu, Jiankun
TI  - The clinicopathological features and prognosis of multifocal high-grade gliomas in adults with <em>H3F3A</em> mutation
AID  - 10.17712/nsj.2023.1.20220080
DP  - 2023 Jan 01
TA  - Neurosciences Journal
PG  - 42--47
VI  - 28
IP  - 1
4099  - http://nsj.org.sa/content/28/1/42.short
4100  - http://nsj.org.sa/content/28/1/42.full
SO  - Neurosciences (Riyadh)2023 Jan 01; 28
AB  - Objectives: To explore the clinicopathological features and prognosis of multifocal high-grade gliomas (M-HGGs) with H3F3A mutation in adults.Methods: Four adult patients with H3F3A-mutant M-HGGs who were treated at our institution from August 2020 to December 2021 were reviewed, including clinical, pathological and radiologic data. A series of 16 adult patients with M-HGGs without H3F3A mutation was used as a comparative group. Progression-free survival (PFS) and overall survival (OS) were compared between the groups using the Kaplan–Meier method.Results: All patients were IDH wild-type and TERT wild-type, and P53 was overexpressed. A patient with the H3 G34R mutation and 1 of 3 patients with the H3 K27 M mutation had MGMT promoter methylation. The lesions with the H3 G34R mutation were located in the cerebral hemisphere; the lesions with H3 K27 alterations were mainly in the midline structure, and the cerebral hemisphere could also be involved. One patient underwent subtotal resection (STR), and 3 patients underwent biopsy. All patients received radiotherapy, and the median PFS and OS were 9.5 months and 14.5 months, respectively. The clinical outcomes were similar to those of non-H3F3A-mutated M-HGGs patients (median PFS and OS were 7.0 months and 18.0 months, respectively).Conclusion: We describe the clinicopathological features and outcomes of 4 adult M-HGGs patients with H3F3A mutation, and found this mutation doesn’t appear to have a negative outcome with the administration of current therapies.