PT - JOURNAL ARTICLE AU - Ali M. Al Khathaami AU - Bayan Al Bdah AU - Abdulmjeed Alnosair AU - Abdulkarim Alturki AU - Rayan Alrebdi AU - Shorug Alwayili AU - Sulaiman Alhamzah AU - Nasser D. Alotaibi TI - Predictors of poor outcome in embolic stroke of undetermined source AID - 10.17712/nsj.2019.3.20190005 DP - 2019 Jul 01 TA - Neurosciences Journal PG - 164--167 VI - 24 IP - 3 4099 - http://nsj.org.sa/content/24/3/164.short 4100 - http://nsj.org.sa/content/24/3/164.full SO - Neurosciences (Riyadh)2019 Jul 01; 24 AB - Objectives: To identify the clinical predictors of death or disability at discharge.Methods: We retrospectively reviewed all ischemic stroke patients admitted to the stroke unit of King Abdulaziz Medical City, Riyadh, Saudi Arabia, from February 2016 - July 2018. We applied the Cryptogenic Stroke/ESUS International Working Group Embolic stroke of undetermined source (ESUS) criteria. We compared patients with poor outcomes (death or modified Rankin Scale [mRS] score >2) to those with favorable outcomes. Multivariate logistic regression was used to identify predictors of poor outcome. The regression model included age >60 years, gender, body mass index >25 kg/m2, smoking history, comorbidities, previous ischemic/transient ischemic attack, pre-stroke mRS score >1, National Institutes of Health Stroke Scale (NIHSS) score at admission >5, pre-stroke antiplatelet use, and thrombolysis treatment.Results: Out of 147 patients who met the ESUS criteria, 28.8% had poor outcomes. Predictors of poor outcome were NIHSS score >5 (odds ratio [OR] 11.1, 95% confidence interval [CI] 4.4–28.2), pre-stroke mRS score >1 (OR 3.7, 95% CI 1.14–11.59), and age >60 years (OR 2.4, 95% CI 1.14–5.22).Conclusion: A significant proportion of ESUS patients were dead or disabled at discharge. Poor outcome was more in older patients with pre-stroke functional disability and moderate to severe stroke.