PT  - JOURNAL ARTICLE
AU  - Al Khathaami, Ali M.
AU  - Al Bdah, Bayan
AU  - Alnosair, Abdulmjeed
AU  - Alturki, Abdulkarim
AU  - Alrebdi, Rayan
AU  - Alwayili, Shorug
AU  - Alhamzah, Sulaiman
AU  - Alotaibi, Nasser D.
TI  - Predictors of poor outcome in embolic stroke of undetermined source
AID  - 10.17712/nsj.2019.3.20190005
DP  - 2019 Jul 01
TA  - Neurosciences Journal
PG  - 164--167
VI  - 24
IP  - 3
4099  - http://nsj.org.sa/content/24/3/164.short
4100  - http://nsj.org.sa/content/24/3/164.full
SO  - Neurosciences (Riyadh)2019 Jul 01; 24
AB  - Objectives: To identify the clinical predictors of death or disability at discharge.Methods: We retrospectively reviewed all ischemic stroke patients admitted to the stroke unit of King Abdulaziz Medical City, Riyadh, Saudi Arabia, from February 2016 - July 2018. We applied the Cryptogenic Stroke/ESUS International Working Group Embolic stroke of undetermined source (ESUS) criteria. We compared patients with poor outcomes (death or modified Rankin Scale [mRS] score >2) to those with favorable outcomes. Multivariate logistic regression was used to identify predictors of poor outcome. The regression model included age >60 years, gender, body mass index >25 kg/m2, smoking history, comorbidities, previous ischemic/transient ischemic attack, pre-stroke mRS score >1, National Institutes of Health Stroke Scale (NIHSS) score at admission >5, pre-stroke antiplatelet use, and thrombolysis treatment.Results: Out of 147 patients who met the ESUS criteria, 28.8% had poor outcomes. Predictors of poor outcome were NIHSS score >5 (odds ratio [OR] 11.1, 95% confidence interval [CI] 4.4–28.2), pre-stroke mRS score >1 (OR 3.7, 95% CI 1.14–11.59), and age >60 years (OR 2.4, 95% CI 1.14–5.22).Conclusion: A significant proportion of ESUS patients were dead or disabled at discharge. Poor outcome was more in older patients with pre-stroke functional disability and moderate to severe stroke.