RT Journal Article SR Electronic T1 Predictors of poor outcome in embolic stroke of undetermined source JF Neurosciences Journal JO Neurosciences (Riyadh) FD Prince Sultan Military Medical City SP 164 OP 167 DO 10.17712/nsj.2019.3.20190005 VO 24 IS 3 A1 Ali M. Al Khathaami A1 Bayan Al Bdah A1 Abdulmjeed Alnosair A1 Abdulkarim Alturki A1 Rayan Alrebdi A1 Shorug Alwayili A1 Sulaiman Alhamzah A1 Nasser D. Alotaibi YR 2019 UL http://nsj.org.sa/content/24/3/164.abstract AB Objectives: To identify the clinical predictors of death or disability at discharge.Methods: We retrospectively reviewed all ischemic stroke patients admitted to the stroke unit of King Abdulaziz Medical City, Riyadh, Saudi Arabia, from February 2016 - July 2018. We applied the Cryptogenic Stroke/ESUS International Working Group Embolic stroke of undetermined source (ESUS) criteria. We compared patients with poor outcomes (death or modified Rankin Scale [mRS] score >2) to those with favorable outcomes. Multivariate logistic regression was used to identify predictors of poor outcome. The regression model included age >60 years, gender, body mass index >25 kg/m2, smoking history, comorbidities, previous ischemic/transient ischemic attack, pre-stroke mRS score >1, National Institutes of Health Stroke Scale (NIHSS) score at admission >5, pre-stroke antiplatelet use, and thrombolysis treatment.Results: Out of 147 patients who met the ESUS criteria, 28.8% had poor outcomes. Predictors of poor outcome were NIHSS score >5 (odds ratio [OR] 11.1, 95% confidence interval [CI] 4.4–28.2), pre-stroke mRS score >1 (OR 3.7, 95% CI 1.14–11.59), and age >60 years (OR 2.4, 95% CI 1.14–5.22).Conclusion: A significant proportion of ESUS patients were dead or disabled at discharge. Poor outcome was more in older patients with pre-stroke functional disability and moderate to severe stroke.