RT Journal Article
SR Electronic
T1 Predictors of poor outcome in embolic stroke of undetermined source
JF Neurosciences Journal
JO Neurosciences (Riyadh)
FD Prince Sultan Military Medical City
SP 164
OP 167
DO 10.17712/nsj.2019.3.20190005
VO 24
IS 3
A1 Al Khathaami, Ali M.
A1 Al Bdah, Bayan
A1 Alnosair, Abdulmjeed
A1 Alturki, Abdulkarim
A1 Alrebdi, Rayan
A1 Alwayili, Shorug
A1 Alhamzah, Sulaiman
A1 Alotaibi, Nasser D.
YR 2019
UL http://nsj.org.sa/content/24/3/164.abstract
AB Objectives: To identify the clinical predictors of death or disability at discharge.Methods: We retrospectively reviewed all ischemic stroke patients admitted to the stroke unit of King Abdulaziz Medical City, Riyadh, Saudi Arabia, from February 2016 - July 2018. We applied the Cryptogenic Stroke/ESUS International Working Group Embolic stroke of undetermined source (ESUS) criteria. We compared patients with poor outcomes (death or modified Rankin Scale [mRS] score >2) to those with favorable outcomes. Multivariate logistic regression was used to identify predictors of poor outcome. The regression model included age >60 years, gender, body mass index >25 kg/m2, smoking history, comorbidities, previous ischemic/transient ischemic attack, pre-stroke mRS score >1, National Institutes of Health Stroke Scale (NIHSS) score at admission >5, pre-stroke antiplatelet use, and thrombolysis treatment.Results: Out of 147 patients who met the ESUS criteria, 28.8% had poor outcomes. Predictors of poor outcome were NIHSS score >5 (odds ratio [OR] 11.1, 95% confidence interval [CI] 4.4–28.2), pre-stroke mRS score >1 (OR 3.7, 95% CI 1.14–11.59), and age >60 years (OR 2.4, 95% CI 1.14–5.22).Conclusion: A significant proportion of ESUS patients were dead or disabled at discharge. Poor outcome was more in older patients with pre-stroke functional disability and moderate to severe stroke.