TY - JOUR T1 - Exploring the outcome of multiple sclerosis among Saudi adult patients JF - Neurosciences Journal JO - Neurosciences (Riyadh) SP - 168 LP - 175 DO - 10.17712/nsj.2019.3.20180034 VL - 24 IS - 3 AU - Azhar M. Alanazi AU - Jinan R. Al-Rashoud AU - Jumanah M. Aljahani AU - Ahlam F. Alotaibi AU - Alaa M. Althubaiti AU - Suleiman M. Kojan AU - Mohammed A. Aljumah AU - Ahmad A. Abulaban Y1 - 2019/07/01 UR - http://nsj.org.sa/content/24/3/168.abstract N2 - Objectives: To assess the outcome and impact of multiple sclerosis (MS) using validated Arabic versions of the Barthel index (BI) multiple sclerosis impact scale (MSIS-29), the modified Rankin scale (mRS), and the expanded disability status scale (EDSS).Methods: A cross-sectional study conducted at King Abdulaziz Medical City in Riyadh, Kingdom of Saudi Arabia, during July-November 2017. All Saudi adult patients diagnosed with MS between 2000-2016 (269 patients) were included. Patients were contacted via phone calls and were assessed using a newly developed and validated multi-component questionnaire that included demographic data, disease course, and Arabic versions of the scales.Results: Out of 269 patients, 210 (78.2%) responded. The average patient age was 37.44±10.3 years. The majority were females (69.5%). Only, 51 (24.3%) patients reported worsening conditions. Annually, the average relapse rate was 2.28±1.91. In regard to patient outcomes, 120 (57.1%) showed no significant disability in mRS, 146 (69.5%) were ambulatory without aid in EDSS, and 185 (89.4%) were independent in BI scores. The average MSIS-29-PHYS score was 33.6±27.6 and MSIS-29-PSYCH score was 38.2±25.8. Modified Rankin scale and EDSS were significantly associated with the current use of disease-modifying therapy (DMT). Modified Rankin scale was negatively associated with delayed diagnosis. Barthel index showed significant association with medication compliance and the absence of attacks.Conclusion: Majority of patients had a favorable outcome that was linked with the use of DMT, compliance, early diagnosis, and absence of attacks. ER -