RT Journal Article
SR Electronic
T1 A rare case of autoimmune limbic encephalitis: an uncharted territory!
JF Neurosciences Journal
JO Neurosciences (Riyadh)
FD Prince Sultan Military Medical City
SP 292
OP 297
DO 10.17712/nsj.2017.4.20170150
VO 22
IS 4
A1 Hatim Ibrahim
A1 Abdulelah N. Al Jasser
A1 Sonia A. Khan
A1 Kalthoum G. Tlili
YR 2017
UL http://nsj.org.sa/content/22/4/292.abstract
AB Autoimmune encephalitis is rare. Several auto- antibodies are described in autoimmune encephalitis. We describe a case of autoimmune limbic encephalitis associated with positive voltage gated potassium channel (VGKC) antibodies and positive leucine-rich glioma inactivated protein 1 antibodies (LGI1). A 33-year-old Saudi housewife, she presented with 2 months history of cognitive deterioration and recurrent left facio-brachial dystonic seizures followed by generalized tonic clonic seizures. At times the seizures are preceded by rising epigastric aura and shortness of breath. The neurological examination was normal apart from upgoing left plantar reflex. She had borderline IQ of 76 with impaired verbal fluency and impaired visual and verbal memory. Magnetic resonance imaging of the brain showed right mesial temporal non-enhancing lesion. Cerebrospinal fluid examination was positive for LGI1 and VGKC. Optimal seizure control was achieved with immunotherapy.